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0HGS_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameHGS
DescriptionHepatocyte growth factor-regulated tyrosine kinase substrate (protein pp110) (hrs).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005768 endosome (TAS)
0008285 negative regulation of cell proliferation (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The FYVE zinc finger is named after four proteins that it has been found in: Fab1.OTB/ZK632.12.ac1.nd EEA1. The FYVE finger has been shown to bind two Zn2+ ions . The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG.here + represents a charged residue and X any residue.
  IPR000306:Zinc finger, FYVE-type
The Ubiquitin Interacting Motif (UIM) was first described in the 26S proteasome subunit PSD4/RPN-10 . It is known to bind multiple ubiquitin and was also found in many proteins involved in the endocytic pathway.ncludingthe PSD4/RPN-10/S5a multiubiquitin binding subunit of the 26S proteasome; the VPS27 vacuolar sorting protein; and ataxin-3. protein involved in ataxia disease.
  IPR003903:Ubiquitin interacting motif
The VHS domain is a ~140 residues long domain.hose name is derivedfrom its occurrence in VPS-27.rs and STAM. Based on regions surrounding the domain.HS-proteins can be divided into 4 groups : STAM/EAST/Hbp which all share the domain composition VHS-SH3-ITAM and carry one or two ubiquitin-interacting motifs Proteins with a FYVE domain () C-terminal to VHS which also carry one or two ubiquitin-interacting motifs GGA proteins with a domain composition VHS-GAT (GGA and Tom1) homology domain VHS domain alone or in combination with domains other than those listed above The VHS domain is always found at the N-terminus of proteins suggesting that such topology is important for function. The domain is considered to have a general membrane targeting/cargo recognition role in vesicular trafficking .Resolution of the crystal structure of the VHS domain of Drosophila Hrs andhuman Tom1 revealed that it consists of eight helices arranged in a double-layer superhelix. The existence of conserved patches of residues on the domain surface suggests that VHS domains may be involved in protein-protein recognition and docking. Overall.equence similarity is low (approx 25%) amongst domain family members
  IPR002014:VHS
The epsin NH2-terminal homology (ENTH) domain () is a membrane interacting module composed of a superhelix of alpha-helices. It is present at the NH2-terminus of proteins that often contain consensus sequences for binding to clathrin coat components and their accessory factors.nd therefore function as endocytic adaptors. ENTH domain containing proteins have additional roles in signalling and actin regulation and may have yet other actions in the nucleus. The ENTH domain is structurally similar to the VHS domain. The ENTH domain is approximately 150 amino acids long. The ENTH domain forms a compact globular structure.omposed of eight alpha-helices connected by loops of varying length. Three helical hairpins that are stacked consecutively with a right-handed twist determine the general topology of the domain. This stacking gives the ENTH domain a rectangular appearance when viewed face on. The most highly conserved amino acids fall roughly into two classes: internal residues that are involved in packing and therefore are necessary for structural integrity.nd solvent accessible residues that may be involved in protein-protein interactions . VHS domains are found at the N-termini of select proteins involved in intracellular membrane trafficking. The domain consists of eight helices arranged in a superhelix. The surface of the domain has two main features: a basic patch on one side due to several conserved positively charged residues on helix 3 and a negatively charged ridge on the opposite side.ormed by residues on helix 2. Comparison of the two VHS domains and the ENTH domain reveals a conserved surface.omposed of helices 2 and 4.hat is utilized for protein-protein interactions. In addition.HS domain-containing proteins are also often localized to membranes. It has therefore been suggested that the conserved positively charged surface of helix 3 in VHS and ENTH domains plays a role in membrane binding .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008942:ENTH/VHS
Zinc finger domains (ZnFs) are common.elatively small protein motifs that fold around one or more zinc ions. In addition to their role as a DNA-binding module.nFs have recently been shown to mediate protein:protein and protein:lipid interactions. There are at least 14 different classes of Zn fingers.hich differ in the nature and arrangement of their zinc-binding residues .The FYVE zinc finger domain is conserved from yeast to man.nd is named after four proteins that it has been found in: Fab1.OTB/ZK632.12.ac1.nd EEA1. It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P).hich is found mainly on endosomes .The plant homeodomain (PHD) zinc finger domain has a C4HC3-type motif.nd is widely distributed in eukaryotes.eing found in many chromatin regulatory factors .Both the FYVE and the PHD zinc finger motifs display strikingly similar dimetal(zinc)-bound alpha+beta folds.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011011:Zinc finger, FYVE/PHD-type
IPR002014:VHS 
Evalue:-69.0362091064453 
Location:3-139IPR000306:FYVE 
Evalue:-32.9208183288574 
Location:158-221IPR003903:UIM 
Evalue:-2.18045616149902 
Location:257-274
SequencesProtein: HGS_HUMAN (777 aa)
mRNA: NM_004712
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 39 residues, 77261424-77261538Exon2: 30 residues, 77263039-77263124Exon3: 27 residues, 77263746-77263822Exon4: 33 residues, 77264437-77264530Exon5: 43 residues, 77266138-77266262Exon6: 19 residues, 77267616-77267669Exon7: 25 residues, 77268108-77268177Exon8: 43 residues, 77268881-77269006Exon9: 28 residues, 77270937-77271016Exon10: 35 residues, 77271088-77271187Exon11: 34 residues, 77271304-77271400Exon12: 15 residues, 77272249-77272288Exon13: 50 residues, 77272358-77272502Exon14: 22 residues, 77272598-77272658Exon15: 73 residues, 77273220-77273434Exon16: 59 residues, 77273791-77273964Exon17: 49 residues, 77274041-77274182Exon18: 60 residues, 77274258-77274433Exon19: 46 residues, 77277901-77278035Exon20: 42 residues, 77278129-77278249Exon21: 31 residues, 77278479-77278566Exon22: 204 residues, 77278942-77279550Exon23: 2 residues, -Jump to HGS_HUMAN  
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Loci Cluster (Details)Loci: 4323 76816673-76827450 ~-11K 16811(-)Loci: 4324 77091593-77094422 ~-3K 16823(ACTG1)(-)Loci: 3047 77261424-77279550 ~-18K 16838(HGS)(+)Loci: 3048 77451912-77454066 ~-2K 16852(NPB)(+)Loci: 3049 77603051-77608635 ~-6K 16881(GPS1)(+)Loci: 4325 77629503-77649395 ~-20K 16888(FASN)(-)Loci: 4326 77795530-77824862 ~-29K 16893(CSNK1D)(-)Loci: 4327 78208237-78249802 ~-42K 16919(RAB40B)(-)Loci: 3046 76623556-76705827 ~-82K 16801(BAIAP2)(+)Link out to UCSC