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0HES6_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameHES6
DescriptionTranscription cofactor hes-6 (hairy and enhancer of split 6) (c- hairy1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005667 transcription factor complex (ISS)
0003712 transcription cofactor activity (ISS)
0003700 transcription factor activity (TAS)
0006355 regulation of transcription, DNA-dependent (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain confers specificity among members of the Hairy/E(SPL) family. HES-2 (hairy and enhancer of split 2) is a transcription factor.nd the hairy protein is a pair-rule protein that regulates embryonic segmentation and adult bristle patterning. These proteins are transcriptional repressors of genes that require the BHLH protein for their transcription.
  IPR003650:Orange
Basic helix-loop-helix proteins (bHLH) are a group of eukaryotic transcription factors that exert a determinative influence in a variety of developmental pathways. These transcription factors are characterised by a highly evolutionary conserved bHLH domain that mediates specific dimerisation . They facilitate the conversion of inactive monomers to trans-activating dimers at appropriate stages of development . The bHLH proteins can be classified into discrete categories. One such subdivision according to dimerisation.NA binding and expression characteristics defines seven groups . Class I proteins form dimers within the group or with class II proteins. Class II can only form heterodimers with class I factors. Class III factors are characterised by the presence of a leucine zipper () adjacent to the bHLH domain. Class IV factors may form homodimers or teterodimers with class III proteins. Class V and class VI proteins act as regulators of class I and class II factors and class VII proteins have a PAS domain ().
  IPR001092:Basic helix-loop-helix dimerisation region bHLH
The helix-loop-helix (HLH) DNA-binding domain consists of a closed bundleof four helices in a left-handed twist with two crossover connections. TheHLH domain directs dimerisation.nd is juxtaposed to basic regions tocreate a DNA interaction interface surface that recognises specific DNAsequences. Basic region/HLH (bHLH) proteins regulate diverse biologicalpathways . bHLH proteins include MyoD .REBPs (sterol regulatory element binding proteins).nd yeast Pho4 (phosphatase system) .In certain proteins the bHLH domain contains a leucine-zipper motif. ThebHLH/leucine zipper (bHLHZip) domain specifies dimerisation within a networkof proteins and determines sequence-specific DNA binding . bHLHZip domains occur in the transcription factors Myc.ad.ax and Usf . This entry is bHLHZip.hich covers the bHLH domain and the leucine zipper motif.hen present.
  IPR011598:Helix-loop-helix DNA-binding
IPR003650:Hairy_orange 
Evalue:-13.4948501586914 
Location:94-138IPR001092:HLH 
Evalue:-9.50863838195801 
Location:26-78
SequencesProtein: HES6_HUMAN (224 aa)
mRNA: AF260237 AK075040 NM_018645
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 328 residues, 238811648-238812631Exon2: 29 residues, 238812866-238812948Exon3: 31 residues, 238813040-238813127Exon4: 70 residues, 238813204-238813409Exon5: 2 residues, -Jump to HES6_HUMANExon1: 434 residues, 238811649-238812948Exon2: 31 residues, 238813040-238813127Exon3: 73 residues, 238813204-238813418Exon4: 2 residues, -Jump to HES6_HUMANExon1: 326 residues, 238811655-238812631Exon2: 27 residues, 238812866-238812942Exon3: 31 residues, 238813040-238813127Exon4: 51 residues, 238813204-238813351Exon5: 2 residues, -Jump to HES6_HUMAN  
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