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0HEM6_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCPOX
DescriptionCoproporphyrinogen iii oxidase, mitochondrial precursor (ec 1.3.3.3) (coproporphyrinogenase) (coprogen oxidase) (cox).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
0004109 coproporphyrinogen oxidase activity (TAS)
0006783 heme biosynthesis (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Coprogen oxidase (i.e. coproporphyrin III oxidase or coproporphyrinogenase) catalyses the oxidative decarboxylation of coproporphyrinogen III to proto-porhyrinogen IX in the haem and chlorophyll biosynthetic pathways . The protein is a homodimer containing two internally bound iron atoms per molecule of native protein . The enzyme is active in the presence of molecular oxygen that actsas an electron acceptor). The enzyme is widely distributed having been found in a variety of eukaryotic and prokaryotic sources.
  IPR001260:Coproporphyrinogen III oxidase
IPR001260:Coprogen_oxidas 
Evalue:-262.0087890625 
Location:145-453
SequencesProtein: HEM6_HUMAN (454 aa)
mRNA: NM_000097
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00228
  Level 3 annotation:
    coproporphyrinogen III oxidase
  Level 2 annotation:
    Porphyrin and chlorophyll metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 442 residues, 99780981-99782304Exon2: 37 residues, 99782940-99783045Exon3: 75 residues, 99786974-99787193Exon4: 49 residues, 99790246-99790388Exon5: 39 residues, 99792165-99792276Exon6: 50 residues, 99792545-99792689Exon7: 218 residues, 99794482-99795131Exon8: 2 residues, -Jump to HEM6_HUMAN  
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