SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0HDAC4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameHDAC4
DescriptionHistone deacetylase 4 (hd4).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (TAS)
0000118 histone deacetylase complex (TAS)
0005634 nucleus (NAS)
0004407 histone deacetylase activity (NAS)
0008134 transcription factor binding (TAS)
0016564 transcriptional repressor activity (TAS)
0030183 B cell differentiation (TAS)
0007049 cell cycle (NAS)
0016568 chromatin modification (TAS)
0007275 development (NAS)
0006954 inflammatory response (TAS)
0045843 negative regulation of myogenesis (TAS)
0007399 neurogenesis (TAS)
0006355 regulation of transcription, DNA-dependent (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/684561796.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Histones can be reversibly acetylated on several lysine residues.Regulation of transcription is caused in part by thismechanism. Histone deacetylases catalyse the removalof the acetyl group. Histone deacetylases.cetoin utilization proteins and acetylpolyamine amidohydrolases are all members of this ancient protein superfamily .
  IPR000286:Histone deacetylase superfamily
IPR000286:Hist_deacetyl 
Evalue:-108.408935546875 
Location:653-998IPR000286:His_deacetylse 
Evalue:0 
Location:572-608
SequencesProtein: HDAC4_HUMAN (1084 aa)
mRNA: NM_006037
Local Annotation
Synapse Ontology
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
sdb:0043 positive regulation of short-term neuronal synaptic plasticity  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1484 residues, 239635318-239639769Exon2: 49 residues, 239640092-239640234Exon3: 30 residues, 239641381-239641466Exon4: 46 residues, 239653354-239653488Exon5: 41 residues, 239655121-239655240Exon6: 34 residues, 239667727-239667825Exon7: 42 residues, 239668734-239668854Exon8: 31 residues, 239670787-239670875Exon9: 20 residues, 239674191-239674247Exon10: 38 residues, 239676641-239676749Exon11: 17 residues, 239681642-239681689Exon12: 42 residues, 239689408-239689529Exon13: 46 residues, 239694682-239694816Exon14: 64 residues, 239698158-239698345Exon15: 88 residues, 239701685-239701943Exon16: 76 residues, 239713088-239713312Exon17: 68 residues, 239720877-239721076Exon18: 41 residues, 239721159-239721276Exon19: 39 residues, 239726316-239726429Exon20: 46 residues, 239731215-239731347Exon21: 42 residues, 239743284-239743406Exon22: 42 residues, 239750435-239750556Exon23: 52 residues, 239763045-239763196Exon24: 83 residues, 239776465-239776710Exon25: 26 residues, 239823225-239823297Exon26: 82 residues, 239939309-239939550Exon27: 193 residues, 239987007-239987580Exon28: 2 residues, -Jump to HDAC4_HUMAN  
Tune and view alternative isoforms