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0GUSL2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSMA3
DescriptionBeta-glucuronidase-like protein sma3.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0007399 neurogenesis (TAS)
0001501 skeletal development (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates.r between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosylhydrolases.ased on sequence similarity.as led to the definition of 85 different families . This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site . Because the fold of proteins is better conserved than their sequences.ome of the families can be grouped in clans.Glycoside hydrolase family 2 comprises enzymes with several known activities: beta-galactosidase (); beta-mannosidase (); beta-glucuronidase ().These enzymes contain a conserved glutamic acid residue which has been shown .n Escherichia coli lacZ ().o be the general acid/base catalyst in the active site of the enzyme. This entry describes the immunoglobulin-like beta-sandwich domain .
  IPR006102:Glycoside hydrolase family 2, immunoglobulin-like beta-sandwich
O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates.r between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosylhydrolases.ased on sequence similarity.as led to the definition of 85 different families . This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site . Because the fold of proteins is better conserved than their sequences.ome of the families can be grouped in clans.Glycoside hydrolase family 2 comprises enzymes with several known activities: beta-galactosidase (); beta-mannosidase (); beta-glucuronidase ().Glycoside hydrolase family 20 consists of enzymes such as chitobiases and beta-hexosaminidases ().n which this immunoglobulin-like domain occurs at the C-terminus . This entry describes the immunoglobulin-like beta-sandwich domain that consists of seven beta-strands in two sheets with a Greek-key topology.lthough some members may have extra strands. This fold is found in domains of glycoside hydrolase families 2 and 20. The function of this domain is unknown.
  IPR013812:Glycoside hydrolase, families 2 and 20, immunoglobulin-like beta-sandwich
IPR006102:Glyco_hydro_2 
Evalue:-13.0087738037109 
Location:7-77
SequencesProtein: GUSL2_HUMAN (140 aa)
mRNA: AK097091 BC050737
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 58 residues, 70051445-70051616Exon2: 13 residues, 70081159-70081193Exon3: 54 residues, 70082659-70082815Exon4: 64 residues, 70117020-70117208Exon5: 30 residues, 70120790-70120875Exon6: 60 residues, 70122714-70122889Exon7: 167 residues, 70327360-70327856Exon8: 2 residues, -Jump to GUSL2_HUMANExon1: 64 residues, 70232269-70232459Exon2: 38 residues, 70233407-70233516Exon3: 531 residues, 70248523-70250112Exon4: 2 residues, -Jump to SERF1_HUMANExon1: 82 residues, 70256523-70256767Exon2: 26 residues, 70270421-70270493Exon3: 42 residues, 70272971-70273091Exon4: 69 residues, 70273940-70274141Exon5: 53 residues, 70274300-70274453Exon6: 34 residues, 70276240-70276336Exon7: 39 residues, 70277648-70277759Exon8: 20 residues, 70283523-70283577Exon9: 192 residues, 70284021-70284592Exon10: 2 residues, -Jump to SMN_HUMANLoci index, Chromosomal location, Length, Possible relational loci clusterExon1: 58 residues, 69176325-69176496Exon2: 13 residues, 69205246-69205280Exon3: 54 residues, 69206746-69206902Exon4: 64 residues, 69241957-69242145Exon5: 30 residues, 69245740-69245825Exon6: 60 residues, 69247663-69247838Exon7: 177 residues, 69451887-69452412Exon8: 2 residues, -Jump to GUSL2_HUMANExon1: 64 residues, 69356851-69357041Exon2: 38 residues, 69357989-69358098Exon3: 531 residues, 69373106-69374695Exon4: 2 residues, -Jump to SERF1_HUMANExon1: 82 residues, 69381105-69381349Exon2: 26 residues, 69394997-69395069Exon3: 42 residues, 69397547-69397667Exon4: 69 residues, 69398516-69398717Exon5: 53 residues, 69398876-69399029Exon6: 34 residues, 69400817-69400913Exon7: 39 residues, 69402223-69402334Exon8: 20 residues, 69408103-69408157Exon9: 192 residues, 69408601-69409172Exon10: 2 residues, -Jump to SMN_HUMANLoci index, Chromosomal location, Length, Possible relational loci clusterExon1: 257 residues, 621245-622015Exon2: 47 residues, 622299-622435Exon3: 60 residues, 626907-627082Exon4: 30 residues, 628920-629005Exon5: 64 residues, 632589-632777Exon6: 54 residues, 688709-688865Exon7: 13 residues, 690330-690364Exon8: 74 residues, 719900-720116Exon9: 9 residues, 720136-720158Exon10: 83 residues, 720192-720436Exon11: 2 residues, -Jump to GUSL2_HUMAN  
Loci Cluster (Details)Loci: 4716 70300065-70356279 ~-56K 28969(BIRC1)(-)Loci: 3462 70051445-70327856 ~-276K 28960(SMA3)(+)Link out to UCSC  
Loci: 3515 393545-449737 ~-56K 30164(BIRC1)(+)Loci: 4764 465177-493242 ~-28K 30167(SMN1)(-)Loci: 4765 499652-517517 ~-18K 30169(SERF1A)(-)Loci: 4766 621245-720436 ~-99K 30171(SMA3)(-)Loci: 3514 160403-205618 ~-45K 30155(RAD17)(+)Link out to UCSC