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0GRID1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionGlutamate receptor delta-1 subunit precursor (glur delta-1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains assigned to SynO:
The ability of synapses to modify their synaptic strength in response to activity is a fundamental property of the nervous system and may be an essential component of learning and memory. There are three classes of ionotropic glutamate receptor.amely NMDA (N-methyl-D-aspartate).MPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole-4-propionicacid) and kainate receptors. They are believed to play critical roles in synaptic plasticity. At many synapses in the brain.ransient activation of NMDA receptors leads to a persistent modification in the strength of synaptic transmission mediated by AMPA receptors and kainate receptors can act as the induction trigger for long-term changes in synaptic transmission .
  IPR001320:Ionotropic glutamate receptor
InterPro domains unassigned to SynO:
This describes a ligand binding domain and includes extracellular ligand binding domains of a wide range of receptors.s well as the bacterial amino acid binding proteins of known structure .
  IPR001828:Extracellular ligand-binding receptor
Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. The protein components of these traffic systems include one or two transmembrane protein or two membrane-associated ATP-binding proteins (ABC transporters; see ) and a high affinity periplasmic solute-binding protein. The latter are thought to bind the substrate in the vicinity of the inner membrane.nd to transfer it to a complex of inner membrane proteins for concentration into the cytoplasm.In Gram-positive bacteria which are surrounded by a single membrane and have therefore no periplasmic region.he equivalent proteins are bound to the membrane via an N-terminal lipid anchor. These homolog proteins do not play an integral role in the transport process per se.ut probably serve as receptors to trigger or initiate translocation of the solute throught the membrane by binding to external sites of the integral membrane proteins of the efflux system.In addition.t least some solute-binding proteins function in the initiation of sensory transduction pathways.On the basis of sequence similarities.he vast majority of these solute-binding proteins can be grouped into eight families or clusters.hich generally correlate with the nature of the solute bound.Family 3 groups together specific amino acids and opine-binding periplasmic proteins and a periplasmic homolog with catalytic activity.
  IPR001638:Bacterial extracellular solute-binding protein, family 3
N-Methyl-D-aspartate (NMDA) receptors are members of the glutamate receptorchannel superfamily.hich mediate most of the fast excitory synaptictransmissions in the central nervous system. The superfamily consists of 3subtypes: kainate receptors.lpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors and N-methyl-D-aspartate (NMDA) receptors. The NMDAreceptor is highly permeable to calcium ions and plays a key role in theplasticity of synapses.hich is believed to underlie memory and learning.s well as the development of the nervous system. Abnormal activation hasbeen suggested to lead to neuronal cell death observed in many acute andchronic disorders such as ischemia.troke.lzheimers disease.ndHuntingdons disease .NMDA receptors possess 4 transmembrane (TM) helical domains in the C-terminal half of the sequence and require both glycine and glutamate foractivation.esulting in influx of calcium ions into the cell . Thereceptors can also be activated by polyamine.hey can be blocked bymagnesium ions.nhibited by zinc ions.nd modulated by arachidonic acid.Other non-NMDA glutamate receptors (e.g..ainate) are structurally similarto NMDA receptors.ut are functionally distinct.ossibly as a result ofamino acid substitutions at important positions in the sequence.
  IPR001508:NMDA receptor
SequencesProtein: GRID1_HUMAN (1009 aa)
mRNA: NM_017551
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords,domains)
Either stimulating afferents at high frequency or by directly depolarizing the postsynaptic cell with current injection leads to the Magnalium leaving the AMDAR, then calium and sodium enter the postsynaptic cell and trigger for LTP
sdb:0248 NMDA receptor-dependent LTP  (Evidence:keywords,domains)
sdb:0263 presynaptic LTP  (Evidence:keywords,domains)
sdb:0297 NMDA receptor  (Evidence:keywords,domains)
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK05206
  Level 3 annotation:
    glutamate receptor, ionotropic, delta 1
  Level 2 annotation:
    Neuroactive ligand-receptor interaction
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1050 residues, 87349291-87352438Exon2: 82 residues, 87363143-87363384Exon3: 57 residues, 87369603-87369770Exon4: 67 residues, 87396938-87397134Exon5: 48 residues, 87472739-87472878Exon6: 110 residues, 87474088-87474413Exon7: 68 residues, 87477591-87477789Exon8: 36 residues, 87479249-87479351Exon9: 42 residues, 87604232-87604352Exon10: 56 residues, 87605765-87605927Exon11: 59 residues, 87618746-87618917Exon12: 20 residues, 87665922-87665976Exon13: 70 residues, 87888555-87888761Exon14: 97 residues, 87956100-87956385Exon15: 54 residues, 88113677-88113833Exon16: 62 residues, 88116050-88116230Exon17: 2 residues, -Jump to GRID1_HUMAN