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0GRIA1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGRIA1
DescriptionGlutamate receptor 1 precursor (glur-1) (glur-a) (glur-k1) (glutamate receptor ionotropic, ampa 1) (ampa-selective glutamate receptor 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005886 plasma membrane (TAS)
0008066 glutamate receptor activity (TAS)
0015277 kainate selective glutamate receptor activity (TAS)
0007165 signal transduction (TAS)
0007268 synaptic transmission (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
The ability of synapses to modify their synaptic strength in response to activity is a fundamental property of the nervous system and may be an essential component of learning and memory. There are three classes of ionotropic glutamate receptor.amely NMDA (N-methyl-D-aspartate).MPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole-4-propionicacid) and kainate receptors. They are believed to play critical roles in synaptic plasticity. At many synapses in the brain.ransient activation of NMDA receptors leads to a persistent modification in the strength of synaptic transmission mediated by AMPA receptors and kainate receptors can act as the induction trigger for long-term changes in synaptic transmission .
  IPR001320:Ionotropic glutamate receptor
InterPro domains unassigned to SynO:
This describes a ligand binding domain and includes extracellular ligand binding domains of a wide range of receptors.s well as the bacterial amino acid binding proteins of known structure .
  IPR001828:Extracellular ligand-binding receptor
N-Methyl-D-aspartate (NMDA) receptors are members of the glutamate receptorchannel superfamily.hich mediate most of the fast excitory synaptictransmissions in the central nervous system. The superfamily consists of 3subtypes: kainate receptors.lpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors and N-methyl-D-aspartate (NMDA) receptors. The NMDAreceptor is highly permeable to calcium ions and plays a key role in theplasticity of synapses.hich is believed to underlie memory and learning.s well as the development of the nervous system. Abnormal activation hasbeen suggested to lead to neuronal cell death observed in many acute andchronic disorders such as ischemia.troke.lzheimers disease.ndHuntingdons disease .NMDA receptors possess 4 transmembrane (TM) helical domains in the C-terminal half of the sequence and require both glycine and glutamate foractivation.esulting in influx of calcium ions into the cell . Thereceptors can also be activated by polyamine.hey can be blocked bymagnesium ions.nhibited by zinc ions.nd modulated by arachidonic acid.Other non-NMDA glutamate receptors (e.g..ainate) are structurally similarto NMDA receptors.ut are functionally distinct.ossibly as a result ofamino acid substitutions at important positions in the sequence.
  IPR001508:NMDA receptor
IPR001320:Lig_chan 
Evalue:-159.552841186523 
Location:536-827IPR001828:ANF_receptor 
Evalue:-66.3979415893555 
Location:37-373IPR001508:NMDARECEPTOR 
Evalue:0 
Location:452-480
SequencesProtein: GRIA1_HUMAN (906 aa)
mRNA: NM_000827
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords,domains)
Either stimulating afferents at high frequency or by directly depolarizing the postsynaptic cell with current injection leads to the Magnalium leaving the AMDAR, then calium and sodium enter the postsynaptic cell and trigger for LTP
sdb:0248 NMDA receptor-dependent LTP  (Evidence:keywords,domains)
?
sdb:0263 presynaptic LTP  (Evidence:keywords,domains)
?
sdb:0297 NMDA receptor  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK05197
  Level 3 annotation:
    glutamate receptor, ionotropic, AMPA 1
  Level 2 annotation:
    Neuroactive ligand-receptor interaction
    Ion channels
    Long-term potentiation
    Long-term depression
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 76 residues, 152850498-152850723Exon2: 48 residues, 152853680-152853818Exon3: 82 residues, 153006680-153006920Exon4: 63 residues, 153010082-153010267Exon5: 20 residues, 153015571-153015625Exon6: 56 residues, 153034252-153034414Exon7: 58 residues, 153036746-153036914Exon8: 37 residues, 153045977-153046082Exon9: 39 residues, 153057796-153057907Exon10: 71 residues, 153058619-153058826Exon11: 125 residues, 153065449-153065820Exon12: 68 residues, 153124186-153124385Exon13: 84 residues, 153129920-153130168Exon14: 40 residues, 153154373-153154488Exon15: 47 residues, 153162108-153162243Exon16: 194 residues, 153170777-153171354Exon17: 2 residues, -Jump to GRIA1_HUMAN  
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