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0GRASP_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionGeneral receptor for phosphoinositides 1-associated scaffold protein (grp1-associated scaffold protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
PDZ domains are found in diverse signaling proteins in bacteria.easts.lants.nsects and vertebrates . PDZ domains can occur in one or multiple copies and are nearly always found in cytoplasmic proteins. They bind either the carboxyl-terminal sequences of proteins or internal peptide sequences . In most cases.nteraction between a PDZ domain and its target is constitutive.ith a binding affinity of 1 to 10 ┬ÁM. However.gonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. PDZ domain proteins are frequently associated with the plasma membrane. compartment where high concentrations of phosphatidylinositol 4.-bisphosphate (PIP2) are found. Direct interaction between PIP2 and a subset of class II PDZ domains (syntenin.ASK.iam-1) has been demonstrated. PDZ domains consist of 80 to 90 amino acids comprising six beta-strands (betaA to betaF) and two alpha-helices. and B.ompactly arranged in a globular structure. Peptide binding of the ligand takes place in an elongated surface groove as an antiparallel beta-strand interacts with the betaB strand and the B helix. The structure of PDZ domains allows binding to a free carboxylate group at the end of a peptide through a carboxylate-binding loop between the betaA and betaB strands.
SequencesProtein: GRASP_HUMAN (395 aa)
mRNA: NM_181711
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 101 residues, 50687014-50687316Exon2: 18 residues, 50689240-50689290Exon3: 20 residues, 50690931-50690986Exon4: 36 residues, 50691089-50691192Exon5: 33 residues, 50693737-50693831Exon6: 24 residues, 50693927-50693994Exon7: 24 residues, 50694185-50694252Exon8: 400 residues, 50694744-50695938Exon9: 2 residues, -Jump to GRASP_HUMAN  
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Loci Cluster (Details)Loci: 2755 50587468-50601120 ~-14K 8882(ACVRL1)(+)Loci: 2756 50631752-50677126 ~-45K 8883(ACVR1B)(+)Loci: 2757 50687014-50695938 ~-9K 8886(GRASP)(+)Loci: 4034 50965965-50971566 ~-6K 8896(KRTHB1)(-)Loci: 2758 50981917-50988684 ~-7K 8897(KRTHB6)(+)Loci: 4035 50994358-51001438 ~-7K 8898(KRTHB3)(-)Loci: 4036 51040058-51047576 ~-8K 8899(KRTHB5)(-)Loci: 4037 51057862-51065684 ~-8K 8900(KRTHB4)(-)Loci: 4038 51104120-51114373 ~-10K 8902(-)Loci: 4039 51148861-51153824 ~-5K 8903(KRT6D)(-)Loci: 4040 51167243-51173287 ~-6K 8904(KRT6A)(-)Loci: 4041 51194627-51200510 ~-6K 8905(KRT5)(-)Loci: 4042 51265639-51281559 ~-16K 8909(-)Loci: 4043 51448205-51457372 ~-9K 8917(KRT2P)(-)Loci: 4044 51486600-51494602 ~-8K 8920(KRT4)(-)Loci: 4045 51577237-51585127 ~-8K 8924(KRT8)(-)Loci: 2759 51629109-51632951 ~-4K 8926(KRT18)(+)Loci: 2761 51948817-51973697 ~-25K 8948(ESPL1)(+)Loci: 4046 52160546-52179538 ~-19K 8970(MAP3K12)(-)Loci: 4047 52186740-52187689 ~-1K 8973(NPFF)(-)Loci: 4048 52345211-52356779 ~-12K 8978(ATP5G2)(-)Loci: 2754 50271286-50488365 ~-217K 8878(SCN8A)(+)Link out to UCSC