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0GPR92_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGPR92
DescriptionProbable g-protein coupled receptor 92.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .In addition to their role in energy metabolism.urines (especiallyadenosine and adenine nucleotides) produce a wide range of pharmacologicaleffects mediated by activation of cell surface receptors. ATP is aco-transmitter in sympathetic nerves in the autonomic nervous system.here it exerts an important physiological role in the regulation ofsmooth muscle activity.timulating relaxation of intestinal smooth muscleand contraction of the bladder. Receptors for adenine nucleotides areinvolved in a number of other physiological pathways.ncluding stimulationof platelet activation by ADP.hich is released from the vascularendothelium following injury. ATP has excitatory effects in the CNS .ATP and UTP stimulate phophoinositide metabolism in some tissues via anovel receptor.ermed a nucleotide receptor or P2U.The P2Y receptor is found in smooth muscle (e.g..aeni caeci) and invascular tissue.here it induces vasodilation through endothelium-dependentrelease of nitric oxide. The receptor activates phosphoinositide metabolismthrough a pertussis-toxin-insensitive G-protein.robably belonging tothe Gi/Go class .
  IPR002286:P2 purinoceptor
IPR000276:7tm_1 
Evalue:-59.2006607055664 
Location:39-297
SequencesProtein: GPR92_HUMAN (372 aa)
mRNA: NM_020400
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 877 residues, 6598261-6600891Exon2: 73 residues, 6615333-6615548Exon3: 2 residues, -Jump to GPR92_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4009 6326275-6354976 ~-29K 8222(SCNN1A)(-)Loci: 2731 6424326-6431144 ~-7K 8225(TNFRSF7)(+)Loci: 4010 6441666-6450104 ~-8K 8228(VAMP1)(-)Loci: 4011 6518966-6535498 ~-17K 8239(-)Loci: 4012 6549509-6586812 ~-37K 8245(CHD4)(-)Loci: 4013 6598261-6615548 ~-17K 8247(GPR92)(-)Loci: 2732 6703481-6711289 ~-8K 8256(COPS7A)(+)Loci: 2733 6846966-6850253 ~-3K 8271(TPI1)(+)Loci: 2734 7174236-7201985 ~-28K 8292(CLSTN3)(+)Loci: 4008 5928407-6103946 ~-176K 8213(VWF)(-)Link out to UCSC