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0GPM6A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionNeuronal membrane glycoprotein m6-a (m6a).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0009986 cell surface (IEP)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The myelin sheath is a multi-layered membrane.nique to the nervous system.hat functions as an insulator to greatly increase the velocity of axonal impulse conduction . Myelin proteolipid protein (PLP or lipophilin) is the major myelin protein from the central nervous system (CNS). It probably plays an important role in the formation or maintenance of the multilamellar structure of myelin. In man point mutations in PLP are the cause of Pelizaeus-Merzbacher disease (PMD). neurologic disorder of myelin metabolism. In animals dismyelinating diseases such as mouse jimpy (jp).at md.r dog shaking pup are also caused by mutations in PLP.PLP is a highly conserved hydrophobic protein of 276 to 280 amino acids which seems to contain four transmembrane segments.wo disulphide bonds and which covalently binds lipids (at least six palmitate groups in mammals) .PLP is highly related to M6. neuronal membran glycoprotein .
  IPR001614:Myelin proteolipid protein PLP
SequencesProtein: GPM6A_HUMAN (278 aa)
mRNA: NM_201591
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 707 residues, 176791082-176793202Exon2: 24 residues, 176798273-176798339Exon3: 27 residues, 176798897-176798974Exon4: 53 residues, 176809978-176810132Exon5: 54 residues, 176831824-176831981Exon6: 66 residues, 176859719-176859912Exon7: 282 residues, 176970335-176971176Exon8: 2 residues, -Jump to GPM6A_HUMAN  
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