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0GPDM_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGPD2
DescriptionGlycerol-3-phosphate dehydrogenase, mitochondrial precursor (ec 1.1.99.5) (gpd-m) (gpdh-m) (mtgpd).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005509 calcium ion binding (TAS)
0004368 glycerol-3-phosphate dehydrogenase activity (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase ().arcosine oxidase beta subunit ().-alanine oxidase ().-aspartate oxidase (). D-amino acid oxidase () (DAMOX or DAO) is an FAD flavoenzyme that catalyzes the oxidation of neutral and basic D-amino acids into their corresponding keto acids. DAOs have been characterized and sequenced in fungi and vertebrates where they are known to be located in the peroxisomes. D-aspartate oxidase () (DASOX) is an enzyme.tructurally related to DAO.hich catalyzes the same reaction but is active only toward dicarboxylic D-amino acids. In DAO. conserved histidine has been shown to be important for the enzymes catalytic activity.
  IPR006076:FAD dependent oxidoreductase
FAD-dependent glycerol-3-phosphate dehydrogenase (G3PDH; ) catalyzesthe conversion of glycerol-3-phosphate into dihydroxyacetone phosphate: sn-glycerol-3-phosphate + acceptor = glycerone phosphate + reduced acceptorInsulin exposure often stimulates G3PDHactivity and thus is key to reducing the effects of the diseasediabetes. In obese people.here insulin resistance has been demonstrated.he amount of G3PDH has been shown to be correspondingly lower thanthat in normal weight people .In bacteria it is associated with the utilization of glycerol coupled torespiration. In Escherichia coli and Haemophilus influenzae.wo isozymes are known: one expressed underanaerobic conditions (gene glpA) and one in aerobic conditions (gene glpD). Ineukaryotes. mitochondrial form of GPD participates in the glycerol phosphateshuttle in conjunction with an NAD-dependent cytoplasmic GPD () . This mechanism is responsible forthe preservation of a redox balance . In this environment.he enzymehas been recorded to increase activity in the presence of calcium .These enzymes are proteins of about 60 to 70 Kd which contain a probableFAD-binding domain in their N-terminal extremity. The mammalian enzyme differsfrom the bacterial or yeast proteins by having an EF-hand calcium-bindingregion (see ) in its C-terminal extremity.
  IPR000447:FAD-dependent glycerol-3-phosphate dehydrogenase
Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both side by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1.... and 12; these residues are denoted by X...Y.X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand).
  IPR002048:Calcium-binding EF-hand
This domain consists of a duplication of two EF-hand units.here each unit is composed of two helices connected by a twelve-residue calcium-binding loop. The calcium ion in the EF-hand loop is coordinated in a pentagonal bipyramidal configuration. Many calcium-binding proteins contain an EF-hand type calcium-binding domain . These include: calbindin D9K.100 proteins such as calcyclin.olcalcin phl p 7 (a calcium-binding pollen allergen).steonectin.arvalbumin.almodulin family of proteins (troponin C.altractin.dc4p.yosin essential chain.alcineurin.ecoverin.eurocalcin).lasmodial-specific CaII-binding protein Cbp40.enta-EF-Hand proteins (sorcin.rancalcin.alpain).s well as multidomain proteins such as phosphoinositide-specific phospholipase C.ystrophin.b1 and alpha-actinin. The fold consists of four helices and an open array of two hairpins.
  IPR011992:EF-Hand type
IPR006076:DAO 
Evalue:-68.7958831787109 
Location:71-441IPR002048:efhand 
Evalue:-5.13076829910278 
Location:663-691IPR002048:efhand 
Evalue:-1.79587996006012 
Location:627-655
SequencesProtein: GPDM_HUMAN (727 aa)
mRNA: NM_000408
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00111
  Level 3 annotation:
    glycerol-3-phosphate dehydrogenase
  Level 2 annotation:
    Glycerophospholipid metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 36 residues, 157001165-157001271Exon2: 38 residues, 157040855-157040965Exon3: 59 residues, 157060801-157060973Exon4: 43 residues, 157075553-157075678Exon5: 34 residues, 157076977-157077075Exon6: 56 residues, 157078090-157078254Exon7: 57 residues, 157114365-157114530Exon8: 50 residues, 157115359-157115504Exon9: 66 residues, 157122146-157122340Exon10: 47 residues, 157133582-157133717Exon11: 60 residues, 157134120-157134296Exon12: 46 residues, 157134844-157134976Exon13: 55 residues, 157135891-157136050Exon14: 39 residues, 157143646-157143759Exon15: 28 residues, 157143843-157143922Exon16: 35 residues, 157144447-157144546Exon17: 206 residues, 157147550-157148162Exon18: 2 residues, -Jump to GPDM_HUMAN  
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