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0GP133_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGPR133
DescriptionProbable g-protein coupled receptor 133 precursor (g-protein coupled receptor pgr25).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (TAS)
0004930 G-protein coupled receptor activity (TAS)
0007186 G-protein coupled receptor protein signalin... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The secretin-like GPCRs include secretin .alcitonin .arathyroid hormone/parathyroid hormone-related peptides and vasoactive intestinal peptide .ll of which activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these families: the secretin-like receptors thus bear their own unique 7TM signature.
  IPR000832:GPCR, family 2, secretin-like
This domain has been termed the GPS domain (for GPCR proteolytic site).ecause it contains a cleavage site in latrophilin . However this region in latrophilin is found in many otherwise unrelated cell surface receptors . There is no evidence currently that this domain provides a cleavage site in any of the other receptors. However the peptide bond that is cleaved in latrophilin is between Leu and Thr residues that are conserved in some of the other receptors GPS domains are about 50 residues long and contain either 2 or 4 cysteine residues that are likely to form disulphide bridges. Based on conservation of these cysteines the following pairing can be predicted.
  IPR000203:GPS
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. It has been suggested that the cAMP receptors coordinate aggregation ofindividual cells into a multicellular organism.nd regulate the expressionof a large number of developmentally-regulated genes . The amino acidsequences of the receptors contain high proportions of hydrophobic residuesgrouped into 7 domains.n a manner reminiscent of the rhodopsins and otherreceptors believed to interact with G-proteins. However.hile a similar3D framework has been proposed to account for this.here is no significantsequence similarity between these families: the cAMP receptors thus beartheir own unique 7TM signature.
  IPR000848:cAMP-type GPCR
Lectins and glucanases exhibit the common property of reversibly binding to specific complex carbohydrates. The lectins/glucanases are a diverse group of proteins found in a wide range of species from prokaryotes to humans. The different family members all contain a concanavalin A-like domain.hich consists of a sandwich of 12-14 beta strands in two sheets with a complex topology. Members of this family are diverse.nd include the lectins: legume lectins.ereal lectins.iral lectins.nd animal lectins. Plant lectins function in the storage and transport of carbohydrates in seeds.he binding of nitrogen-fixing bacteria to root hairs.he inhibition of fungal growth or insect feeding.nd in hormonally regulated plant growth . Protein members include concanavalin A (Con A).avin.solectin I.ectin IV.oybean agglutinin and lentil lectin. Animal lectins include the galectins.hich are S-type lactose-binding and IgE-binding proteins such as S-lectin.LC protein.alectin1.alectin2.alectin3 CRD.nd Congerin I . Other members with a Con A-like domain include the glucanases and xylanases. Bacterial and fungal beta-glucanases.uch as Bacillus 1-3.-4-beta-glucanse.arry out the acid catalysis of beta-glucans found in microorganisms and plants . Similarly.appa-Carrageenase degrades kappa-carrageenans from marine red algae cell walls . Xylanase and cellobiohydrolase I degrade hemicellulose and cellulose.espectively . There are many Con A-like domains found in proteins involved in cell recognition and adhesion. For example.everal viral and bacterial toxins carry Con A-like domains. Examples include the Clostridium neurotoxins responsible for the neuroparalytic effects of botulism and tetanus . The Pseudomonas exotoxin A. virulence factor which is highly toxic to eukaryotic cells.ausing the arrest of protein synthesis.ontains a Con A-like domain involved in receptor binding . Cholerae neuraminidase can bind to cell surfaces.ossibly through their Con A-like domains.here they function as part of a mucinase complex to degrade the mucin layer of the gastrointestinal tract . The rotaviral outer capsid protein.P4.as a Con A-like sialic acid binding domain.hich functions in cell attachment and membrane penetration . Con A-like domains also play a role in cell recognition in eukaryotes. Proteins containing a Con A-like domain include the sex hormone-binding globulins which transport sex steroids in blood and regulate their access to target tissues .aminins which are large heterotrimeric glycoproteins involved in basement membrane architecture and function .eurexins which are expressed in hundreds of isoforms on the neuronal cell surface.here they may function as cell recognition molecules and sialidases that are found in both microorganisms and animals.nd function in cell adhesion and signal transduction . Other proteins containing a Con A-like domain include pentraxins and calnexins. The pentraxin PTX3 is a TNFalpha-induced.ecreted protein of adipose cells produced during inflammation . The calnexin family of molecular chaperones is conserved among plants.ungi.nd animals. Family members include Calnexin. type-I integral membrane protein in the endoplasmic reticulum which coordinates the processing of newly synthesized N-linked glycoproteins with their productive folding.almegin. type-I membrane protein expressed mainly in the spermatids of the testis.nd calreticulin. soluble ER lumenal paralog .
  IPR008985:Concanavalin A-like lectin/glucanase
Lectins and glucanases exhibit the common property of reversibly binding to specific complex carbohydrates. The lectins/glucanases are a diverse group of proteins found in a wide range of species from prokaryotes to humans. The different family members all contain a concanavalin A-like domain.hich consists of a sandwich of 12-14 beta strands in two sheets with a complex topology. Members of this family are diverse.nd include the lectins: legume lectins.ereal lectins.iral lectins.nd animal lectins. Plant lectins function in the storage and transport of carbohydrates in seeds.he binding of nitrogen-fixing bacteria to root hairs.he inhibition of fungal growth or insect feeding.nd in hormonally regulated plant growth . Protein members include concanavalin A (Con A).avin.solectin I.ectin IV.oybean agglutinin and lentil lectin. Animal lectins include the galectins.hich are S-type lactose-binding and IgE-binding proteins such as S-lectin.LC protein.alectin1.alectin2.alectin3 CRD.nd Congerin I . Other members with a Con A-like domain include the glucanases. Bacterial and fungal beta-glucanases.uch as Bacillus 1-3.-4-beta-glucanse.arry out the acid catalysis of beta-glucans found in microorganisms and plants . Similarly.appa-Carrageenase degrades kappa-carrageenans from marine red algae cell walls . This entry differs from () by omitting the xylanases and glycosyl hydrolases.
  IPR013320:Concanavalin A-like lectin/glucanase, subgroup
IPR000832:7tm_2 
Evalue:-72.2924270629883 
Location:563-813IPR000203:GPS 
Evalue:-12.6989698410034 
Location:506-556IPR008985:ConA_like_lec_gl 
Evalue:0 
Location:67-246IPR008985:ConA_like_lec_gl 
Evalue:0 
Location:1-17IPR000832:G_PROTEIN_RECEP_F2_1 
Evalue:0 
Location:0-0
SequencesProtein: GP133_HUMAN (874 aa)
mRNA: NM_198827
Local Annotation
Synapse Ontology
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 81 residues, 130004789-130005029Exon2: 14 residues, 130005121-130005158Exon3: 30 residues, 130016960-130017044Exon4: 43 residues, 130021955-130022078Exon5: 62 residues, 130032381-130032561Exon6: 87 residues, 130037592-130037847Exon7: 23 residues, 130041511-130041576Exon8: 54 residues, 130042734-130042890Exon9: 22 residues, 130050880-130050940Exon10: 41 residues, 130053682-130053800Exon11: 39 residues, 130054683-130054794Exon12: 27 residues, 130056469-130056545Exon13: 49 residues, 130064696-130064838Exon14: 26 residues, 130127298-130127372Exon15: 43 residues, 130135037-130135161Exon16: 36 residues, 130155328-130155432Exon17: 39 residues, 130156251-130156363Exon18: 53 residues, 130159221-130159375Exon19: 24 residues, 130168882-130168949Exon20: 24 residues, 130171344-130171411Exon21: 32 residues, 130182222-130182314Exon22: 44 residues, 130186534-130186661Exon23: 16 residues, 130187470-130187512Exon24: 33 residues, 130188634-130188727Exon25: 42 residues, 130189665-130189786Exon26: 2 residues, -Jump to GP133_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2800 129922520-129927316 ~-5K 10021(RAN)(+)Loci: 2801 130004789-130189786 ~-185K 10023(GPR133)(+)Loci: 4085 129840101-129889764 ~-50K 10020(EPIM)(-)Link out to UCSC