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0GOLI_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRNF130
DescriptionGoliath homolog precursor (ring finger protein 130).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (ISS)
0012501 programmed cell death (ISS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The PA (Protease associated) domain is found as an insert domain in diverse proteases.hich include the MEROPS peptidase families A22B.28.nd S8A . The PA domain is also found in a plant vacuolar sorting receptor and members of the RZF family..g. .
  IPR003137:Protease-associated PA
Quality control of intracellular proteins is essential for cellular homeostasis. Molecular chaperones recognise and contribute to the refolding of misfolded or unfolded proteins.hereas the ubiquitin-proteasome system mediates the degradation of such abnormal proteins. Ubiquitin-protein ligases (E3s) determine the substrate specificity for ubiquitylation and have been classified into HECT and RING-finger families. More recently.owever.-box proteins.hich contain a domain (the U box) of about 70 amino acids that is conserved from yeast to humans.ave been identified as a new type of E3 .The RING-finger is a specialised type of Zn-finger of 40 to 60 residues that binds two atoms of zinc.nd is probably involved in mediating protein-protein interactions. . There are two different variants.he C3HC4-type and a C3H2C3-type.hich is clearly related despite the different cysteine/histidine pattern. The latter type is sometimes referred to as RING-H2 finger. The RING domain is a protein interaction domain which has been implicated in a range of diverse biological processes.E3 ubiquitin-protein ligase activity is intrinsic to the RING domain ofc-Cbl and is likely to be a general function of this domain; Various RINGfingers exhibit binding to E2 ubiquitin-conjugating enzymes (Ubcs) .Several 3D-structures for RING-fingers are known . The 3D structure of the zinc ligation system is unique to the RING domain and is referred to as the cross-brace motif. The spacing of the cysteines in such a domain is C-x(2)-C-x(9 to 39)-C-x(1 to 3)-H-x(2 to 3)-C-x(2)-C-x(4 to 48)-C-x(2)-C. Metal ligand pairs one and three co-ordinate to bind one zinc ion.hilst pairs two and four bind the second.s illustrated in the following schematic representation:Note that in the older literature.ome RING-fingers are denoted as LIM-domains. The LIM-domain Zn-finger is a fundamentally different family.lbeit with similar Cys-spacing (see ).
  IPR001841:Zinc finger, RING-type
IPR003137:PA 
Evalue:-20.1135101318359 
Location:71-169IPR001841:zf-C3HC4 
Evalue:-8.82390880584717 
Location:264-304IPR001841:ZF_RING_1 
Evalue:0 
Location:0-0
SequencesProtein: GOLI_HUMAN (419 aa)
mRNA: NM_018434
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 66 residues, 179315079-179315275Exon2: 33 residues, 179323076-179323170Exon3: 70 residues, 179326411-179326616Exon4: 34 residues, 179330015-179330112Exon5: 29 residues, 179337808-179337891Exon6: 26 residues, 179339734-179339806Exon7: 85 residues, 179372666-179372917Exon8: 67 residues, 179400058-179400253Exon9: 220 residues, 179431061-179431715Exon10: 2 residues, -Jump to GOLI_HUMAN  
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Loci Cluster (Details)Loci: 4761 179315079-179431715 ~-117K 30113(RNF130)(-)Loci: 3513 179153591-179156118 ~-3K 30096(LTC4S)(+)Link out to UCSC