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0GMEB2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGMEB2
DescriptionGlucocorticoid modulatory element binding protein 2 (gmeb-2) (parvovirus initiation factor p79) (pif p79) (dna binding protein p79pif).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (TAS)
0003702 RNA polymerase II transcription factor acti... (TAS)
0006366 transcription from RNA polymerase II promoter (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The SAND domain (named after Sp100.IRE-1.ucP41/75.EAF-1) is a conserved~80 residue region found in a number of nuclear proteins.any of whichfunction in chromatin-dependent transcriptional control. These includeproteins linked to various human diseases.uch as the Sp100 (Speckled protein100 kDa).UDR (Nuclear DEAF-1 related).MEB (Glucocorticoid ModulatoryElement Binding) proteins and AIRE-1 (Autoimmune regulator 1) proteins.Proteins containing the SAND domain have a modular structure; the SAND domaincan be associated with a number of other modules.ncluding the bromodomain.he PHD finger and the MYND finger.Because no SAND domain has been found in yeast.t is thought that the SANDdomain could be restricted to animal phyla. Many SAND domain-containingproteins.ncluding NUDR.EAF-1 (Deformed epidermal autoregulatory factor-1)and GMEB.ave been shown to bind DNA sequences specifically. The SAND domainhas been proposed to mediate the DNA binding activity of these proteins .The resolution of the 3D structure of the SAND domain from Sp100b has revealedthat it consists of a novel alpha/beta fold. The SAND domainadopts a compact fold consisting of a strongly twisted.ive-strandedantiparallel beta-sheet with four alpha-helices packing against one side ofthe beta-sheet. The opposite side of the beta-sheet is solvent exposed. Thebeta-sheet and alpha-helical parts of the structure form two distinct regions.Multiple hydrophobic residues pack between these regions to form a structuralcore. A conserved KDWK sequence motif is found within the alpha-helical.ositively charged surface patch. The DNA binding surface has been mapped tothe alpha-helical region encompassing the KDWK motif .
  IPR000770:SAND
The SAND domain (named after Sp100.IRE-1.ucP41/75.EAF-1) is a conserved ~80 residue region found in a number of nuclear proteins.any of which function in chromatin-dependent transcriptional control. These include proteins linked to various human diseases.uch as the Sp100 (Speckled protein 100 kDa).UDR (Nuclear DEAF-1 related).MEB (Glucocorticoid Modulatory Element Binding) proteins and AIRE-1 (Autoimmune regulator 1) proteins.Proteins containing the SAND domain have a modular structure; the SAND domain can be associated with a number of other modules.ncluding the bromodomain.he PHD finger and the MYND finger. Because no SAND domain has been found in yeast.t is thought that the SAND domain could be restricted to animal phyla. Many SAND domain-containing proteins.ncluding NUDR.EAF-1 (Deformed epidermal autoregulatory factor-1) and GMEB.ave been shown to bind DNA sequences specifically. The SAND domain has been proposed to mediate the DNA binding activity of these proteins . Structurally.he SAND domain consists of a novel alpha/beta fold.hich has a core of three short helices packed against a barrel-like beta-sheet; it is structurally similar to the SH3-like fold.Other proteins display domains that are structurally similar to the SAND domain. One such example is the SMAD4-binding domain of the oncoprotein Ski.hich is stabilised by a bound zinc atom.nd resembles a SAND domain.n which the corresponding I loop is responsible for DNA binding. Ski is able to disrupt the formation of a functional complex between the Co- and R-SMADs.eading to the repression of TGF-beta.ctivin and BMP responses.esulting in the repression of TGF-signalling .
  IPR010919:SAND-like
IPR000770:SAND 
Evalue:-46.5528411865234 
Location:81-163
SequencesProtein: GMEB2_HUMAN (530 aa)
mRNA: NM_012384
Local Annotation
Synapse Ontology
calcium-regulated transcription factor
sdb:0215 calcium-regulated transcription factor  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1043 residues, 61689398-61692526Exon2: 43 residues, 61693818-61693941Exon3: 48 residues, 61694329-61694467Exon4: 26 residues, 61694807-61694879Exon5: 54 residues, 61697406-61697564Exon6: 36 residues, 61699553-61699657Exon7: 44 residues, 61704761-61704889Exon8: 34 residues, 61706539-61706637Exon9: 205 residues, 61721063-61721673Exon10: 2 residues, -Jump to GMEB2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3279 60906621-60915796 ~-9K 23505(OGFR)(+)Loci: 3280 61337720-61342298 ~-5K 23526(BIRC7)(+)Loci: 4537 61448389-61463100 ~-15K 23536(CHRNA4)(-)Loci: 4538 61507985-61574437 ~-66K 23542(KCNQ2)(-)Loci: 4539 61630221-61639151 ~-9K 23549(PTK6)(-)Loci: 4540 61642606-61649301 ~-7K 23550(SRMS)(-)Loci: 4541 61659883-61676033 ~-16K 23552(PRIC285)(-)Loci: 4542 61689398-61721673 ~-32K 23556(GMEB2)(-)Loci: 3281 61996961-62035838 ~-39K 23585(DNAJC5)(+)Loci: 3282 62082900-62134895 ~-52K 23593(C20orf14)(+)Loci: 3283 62181931-62202435 ~-21K 23600(OPRL1)(+)Loci: 3278 60810633-60864567 ~-54K 23503(NTSR1)(+)Link out to UCSC