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0GLTL2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGALNTL2
DescriptionPolypeptide n-acetylgalactosaminyltransferase-like protein 2 (ec 2.4.1.41) (protein-udp acetylgalactosaminyltransferase-like protein 2) (udp-galnac:polypeptide n-acetylgalactosaminyltransferase- like protein 2) (polypeptide galnac transferase-like protein 2) (galnac-t-like protein 2) (pp-gantase-like protein 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Ricin is a legume lectin from the seeds of the castor bean plant.icinus communis. The seeds are poisonous to people.nimals and insects and just one milligram of ricin can kill an adult. Primary structure analysis has shown the presence of a similar domain in many carbohydrate-recognition proteins like plant and bacterial AB-toxins.lycosidases or proteases . This domain.nown as the ricin B lectin domain.an be present in one or more copies and has been shown in some instance to bind simple sugars.uch as galactose or lactose.The ricin B lectin domain is composed of three homologous subdomains of 40 amino acids (alpha.eta and gamma) and a linker peptide of around 15 residues (lambda). It has been proposed that the ricin B lectin domain arose by gene triplication from a primitive 40 residue galactoside-binding peptide . The most characteristic.hough not completely conserved.equence feature is the presence of a Q-W pattern. Consequently.he ricin B lectin domain as also been refered as the (QxW)3 domain and the three homologous regions as the QxW repeats . A disulphide bond is also conserved in some of the QxW repeats .The 3D structure of the ricin B chain has shown that the three QxW repeats pack around a pseudo threefold axis that is stabilised by the lambda linker . The ricin B lectin domain has no major segments of a helix or beta sheet but each of the QxW repeats contains an omega loop . An idealized omega-loop is a compact.ontiguous segment of polypeptide that traces a loop-shaped path in three-dimensional space; the main chain resembles a Greek omega.
  IPR000772:Ricin B lectin
The biosynthesis of disaccharides.ligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These are enzymes that catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules.orming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar.ucleotide monophospho-sugar and sugar phosphates () and related proteins into distinct sequence based families has been described . This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site . The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences.everal of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form clans.This domain is found in a diverse family of glycosyl transferases that transfer the sugarfrom UDP-glucose.DP-N-acetyl-galactosamine.DP-mannose or CDP-abequose.o a rangeof substrates including cellulose.olichol phosphate and teichoic acids.
  IPR001173:Glycosyl transferase, family 2
The plant cytotoxin ricin is a heterodimer. The A chain.nown to be a specific N-glycosidase.as a prominent active site cleft. The B chain is a two-domain lectin.hich arose from the replication of a primitive sugar binding peptide. The B chain subunit of ricin (RTB)1 binds to mammalian cell membranes by recognizing galactose-containing receptors. RTB has two domains each with three subdomains; tripeptide kinks in the loops from subdomains 1alpha.beta.alpha.nd 2gamma may interact with galactosides. Each of these subdomains has aromatic residues that can interact with the nonpolar face of galactose.nd three of the four subdomain folds (1alpha.beta.nd 2gamma) have polar residues for hydrogen bond formation to the sugar hydroxyls . The family 10 xylanase from Streptomyces olivaceoviridis E-86 contains a (beta/alpha)(8)-barrel as a catalytic domain. family 13 carbohydrate binding module as a xylan binding domain (XBD) and a Gly/Pro-rich linker between them. The crystal structure of this enzyme showed that XBD has three similar subdomains.s indicated by the presence of a triple-repeated sequence.orming a galactose binding lectin fold similar to that found in the ricin toxin B-chain . The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008997:Ricin B-related lectin
IPR000772:Ricin_B_lectin 
Evalue:-34.5686378479004 
Location:505-628IPR001173:Glycos_transf_2 
Evalue:-26.7447280883789 
Location:194-380
SequencesProtein: GLTL2_HUMAN (639 aa)
mRNA: NM_054110
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK00710
  Level 3 annotation:
    polypeptide N-acetylgalactosaminyltransferase
  Level 2 annotation:
    O-Glycan biosynthesis
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 348 residues, 16191159-16192201Exon2: 57 residues, 16212270-16212437Exon3: 70 residues, 16217129-16217334Exon4: 58 residues, 16225013-16225181Exon5: 41 residues, 16227634-16227752Exon6: 67 residues, 16229079-16229274Exon7: 46 residues, 16235913-16236045Exon8: 37 residues, 16236420-16236525Exon9: 50 residues, 16239125-16239269Exon10: 431 residues, 16243864-16245151Exon11: 2 residues, -Jump to GLTL2_HUMAN  
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