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0GLSL_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionGlutaminase liver isoform, mitochondrial precursor (ec (gls) (l-glutamine amidohydrolase) (l-glutaminase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
0004359 glutaminase activity (TAS)
0006520 amino acid metabolism (TAS)

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Domain Architecture (Details)
InterPro domains unassigned to SynO:
This family of enzymes deaminates glutamine to glutamate .
The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. Ankyrin repeats are tandemly repeated modules of about 33 amino acids. They occur in a large number of functionally diverse proteins mainly from eukaryotes. The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers . The repeat has been found in proteins of diverse function such as transcriptional initiators.ell-cycle regulators.ytoskeletal.on transporters and signal transducers. The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it. The conserved fold of the ankyrin repeat unit is known from several crystal and solution structures . Each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90o angle. The repeats stack together to form an L-shaped structure .
This domain is present in the penicillin-binding protein family of beta-lactamases.hich constitute the most common bacterial resistance mechanism against beta-lactam antibiotics . Beta-lactamases appear to have evolved from DD-transpeptidases.hich are penicillin-binding proteins involved in cell wall biosynthesis.nd as such are one of the main targets of beta-lactam antibiotics. Both these proteins adopt a similar structure.onsisting of a cluster of helices and an alpha/beta sandwich. This beta-lactamase/transpeptidase fold is also present in other penicillin-binding proteins.s well as in esterase EstB .nd in D-aminopeptidase (N-terminal domain) . A probable glutaminase from Bacillus subtilis (YbgJ) may adopt a similar structure.nstead of the usual glutaminase fold.
  IPR012338:Penicillin-binding protein, transpeptidase fold
SequencesProtein: GLSL_HUMAN (602 aa)
mRNA: NM_013267
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK01425
  Level 3 annotation:
  Level 2 annotation:
    Nitrogen metabolism
    Glutamate metabolism
    D-Glutamine and D-glutamate metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 231 residues, 55151003-55151694Exon2: 23 residues, 55151823-55151887Exon3: 27 residues, 55152169-55152246Exon4: 22 residues, 55152740-55152802Exon5: 33 residues, 55153278-55153371Exon6: 46 residues, 55153513-55153645Exon7: 61 residues, 55154594-55154771Exon8: 19 residues, 55154896-55154947Exon9: 24 residues, 55155094-55155161Exon10: 21 residues, 55155674-55155733Exon11: 13 residues, 55155995-55156028Exon12: 21 residues, 55157710-55157769Exon13: 56 residues, 55157983-55158147Exon14: 28 residues, 55158233-55158313Exon15: 45 residues, 55159102-55159232Exon16: 42 residues, 55159830-55159952Exon17: 35 residues, 55160338-55160438Exon18: 155 residues, 55167987-55168448Exon19: 2 residues, -Jump to GLSL_HUMAN  
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Loci Cluster (Details)Loci: 2763 54396087-54399754 ~-4K 9024(BLOC1S1)(+)Loci: 2764 54423333-54430331 ~-7K 9030(GDF11)(+)Loci: 2765 54654128-54674745 ~-21K 9056(RAB5B)(+)Loci: 2766 54677309-54685574 ~-8K 9057(SUOX)(+)Loci: 2767 54798296-54802545 ~-4K 9067(+)Loci: 4051 54843395-54869544 ~-26K 9082(SMARCC2)(-)Loci: 4052 54951749-54980442 ~-29K 9095(CS)(-)Loci: 4053 55151003-55168448 ~-17K 9108(GLS2)(-)Loci: 4054 55275981-55316430 ~-40K 9114(BAZ2A)(-)Loci: 4055 55318225-55326119 ~-8K 9115(ATP5B)(-)Loci: 4056 55708568-55730160 ~-22K 9128(MYO1A)(-)Loci: 4050 54364622-54387894 ~-23K 9022(ITGA7)(-)Link out to UCSC