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0GIPR_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGIPR
DescriptionGastric inhibitory polypeptide receptor precursor (gip-r) (glucose- dependent insulinotropic polypeptide receptor).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (TAS)
0005886 plasma membrane (TAS)
0004888 transmembrane receptor activity (TAS)
0007190 adenylate cyclase activation (TAS)
0007166 cell surface receptor linked signal transdu... (TAS)
0006091 generation of precursor metabolites and energy (TAS)
0007584 response to nutrients (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The secretin-like GPCRs include secretin .alcitonin .arathyroid hormone/parathyroid hormone-related peptides and vasoactive intestinal peptide .ll of which activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these families: the secretin-like receptors thus bear their own unique 7TM signature.
  IPR000832:GPCR, family 2, secretin-like
This domain is found in the extracellular part of some hormone receptors including the calcitonin receptor; corticotropin releasing factor receptor 1; diuretic hormone receptor; glucagon-like peptide 1 receptor; and parathyroid hormone peptide receptor.
  IPR001879:Hormone receptor, extracellular
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The secretin-like GPCRs include secretin .alcitonin .arathyroid hormone/parathyroid hormone-related peptides and vasoactive intestinal peptide .ll of which activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these families: the secretin-like receptors thus bear their own unique 7TM signature.Glucose-dependent insulinotropic polypeptide (GIP) plays an important rolein the regulation of postprandial insulin secretion and proinsulin geneexpression of pancreatic beta-cells . The human GIP-receptor encodes a7TM protein that is similar to the human glucagon-like peptide 1(GLP-1)receptor. It is hoped that an understanding of GIP-receptor regulation andsignal transduction will shed light on the hormones failure to exert itsbiological action at the pancreatic B-cell in type II diabetes mellitus.
  IPR001749:Gastric inhibitory polypeptide receptor
IPR000832:7tm_2 
Evalue:-134.88606262207 
Location:134-399IPR001879:HRM 
Evalue:-24.8239078521729 
Location:58-123IPR001749:GIPRECEPTOR 
Evalue:0 
Location:5-25IPR001749:GIPRECEPTOR 
Evalue:0 
Location:422-439IPR001749:GIPRECEPTOR 
Evalue:0 
Location:446-462
SequencesProtein: GIPR_HUMAN (466 aa)
mRNA: NM_000164
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK04580
  Level 3 annotation:
    gastric inhibitory polypeptide receptor
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 19 residues, 50863341-50863396Exon2: 40 residues, 50864574-50864690Exon3: 35 residues, 50865732-50865832Exon4: 38 residues, 50866382-50866490Exon5: 36 residues, 50867948-50868052Exon6: 36 residues, 50869171-50869275Exon7: 50 residues, 50869779-50869924Exon8: 55 residues, 50872046-50872206Exon9: 22 residues, 50872420-50872481Exon10: 25 residues, 50872807-50872877Exon11: 31 residues, 50873003-50873092Exon12: 48 residues, 50873185-50873324Exon13: 16 residues, 50876701-50876743Exon14: 245 residues, 50876826-50877557Exon15: 2 residues, -Jump to GIPR_HUMAN  
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Loci Cluster (Details)Loci: 3116 50100878-50104489 ~-4K 19057(APOE)(+)Loci: 3117 50234137-50266053 ~-32K 19065(SFRS16)(+)Loci: 4398 50407718-50429309 ~-22K 19076(-)Loci: 3118 50446389-50500381 ~-54K 19078(MARK4)(+)Loci: 4399 50546685-50565669 ~-19K 19089(ERCC2)(-)Loci: 4400 50747641-50779917 ~-32K 19109(OPA3)(-)Loci: 4401 50804499-50834509 ~-30K 19111(EML2)(-)Loci: 3119 50863341-50877557 ~-14K 19113(GIPR)(+)Loci: 4402 51134630-51168497 ~-34K 19134(NOVA2)(-)Loci: 3120 51542133-51585943 ~-44K 19149(PPP5C)(+)Loci: 3121 51796351-51805878 ~-10K 19157(CALM1)(+)Loci: 4403 51869413-51911506 ~-42K 19161(PRKD2)(-)Loci: 4404 52033262-52046043 ~-13K 19167(AP2S1)(-)Loci: 3115 50004177-50016517 ~-12K 19053(LU)(+)Link out to UCSC