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0GHC1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSLC25A22
DescriptionMitochondrial glutamate carrier 1 (glutamate/h(+) symporter 1) (solute carrier family 25 member 22).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005743 mitochondrial inner membrane (IDA)
0005386 carrier activity (IDA)
0005313 L-glutamate transporter activity (IDA)
0015813 L-glutamate transport (IDA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane or integral to the membrane of other eukaryotic organelles such as the peroxisome . Such proteins include: ADP.TP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others. Structurally.hese proteins can consist of up to three tandem repeats of a domain of approximately 100 residues.ach domain containing two transmembrane regions.
  IPR001993:Mitochondrial substrate carrier
A variety of substrate carrier proteins that are involved in energy transferare found in the inner mitochondrial membrane . Such proteins include:ADP/ATP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrierprotein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein;and many others.Sequence analysis of selected members of the carrier protein family hassuggested the presence of six transmembrane (TM) domains.ith varying degrees of sequence conservation and hydrophilicity . The TM regions.nd adjacent hydrophilic loops.re more highly conserved than otherregions of the proteins . All members of the family appear to consistof a tripartite structure.ach of the repeated segments being about 100 residuesin length . Each repeat contains two TM domains.he first being morehydrophobic.ith conserved glycyl and prolyl residues. Five of the six TMdomains are followed by the conserved sequence (D/E)-Hy(K/R) {where - denotesany residue.nd Hy is a hydrophobic position} .
  IPR002067:Mitochondrial carrier protein
A variety of substrate carrier proteins that are involved in energy transferare found in the inner mitochondrial membrane . Such proteins include:ADP.TP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrierprotein; phosphate carrier protein; tricarboxylate transport protein (orcitrate transport protein); Graves disease carrier protein; yeastmitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein;and many others.Sequence analysis of selected members of the carrier protein family hassuggested the presence of six transmembrane (TM) domains.ith varyingdegrees of sequence conservation and hydrophilicity . The TM regions.nd adjacent hydrophilic loops.re more highly conserved than otherregions of the proteins . All members of the family appear to consistof a tripartite structure.ach of the repeated segments being ~100 residuesin length . Each repeat contains two TM domains.he first being morehydrophobic.ith conserved glycyl and prolyl residues. Five of the six TMdomains are followed by the conserved sequence (D/E)-Hy(K/R){where - denotesany residue.nd Hy is a hydrophobic position} .Mitochondrial ADP/ATP translocase.n abundant component of the innermembrane.arries ATP from the matrix into the inter-membrane space andtransports ADP back . The protein is an integral membrane protein thatfunctions as a homodimer.
  IPR002113:Adenine nucleotide translocator 1
IPR001993:Mito_carr 
Evalue:-29.9586067199707 
Location:7-98IPR001993:Mito_carr 
Evalue:-22.7695503234863 
Location:224-306IPR001993:Mito_carr 
Evalue:-18.3187580108643 
Location:102-219
SequencesProtein: GHC1_HUMAN (323 aa)
mRNA: NM_024698
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 532 residues, 780475-782068Exon2: 27 residues, 782141-782217Exon3: 53 residues, 782303-782458Exon4: 60 residues, 782552-782727Exon5: 41 residues, 782869-782988Exon6: 32 residues, 783528-783619Exon7: 20 residues, 784457-784513Exon8: 44 residues, 784775-784901Exon9: 63 residues, 784986-785169Exon10: 61 residues, 786042-786221Exon11: 2 residues, -Jump to GHC1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2642 627304-630703 ~-3K 6078(DRD4)(+)Loci: 3928 780475-786221 ~-6K 6091(SLC25A22)(-)Loci: 3929 789178-795245 ~-6K 6092(-)Loci: 2643 915840-1002239 ~-86K 6112(AP2A2)(+)Loci: 3927 192923-197383 ~-4K 6029(-)Link out to UCSC