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0GFRP_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGCHFR
DescriptionGtp cyclohydrolase i feedback regulatory protein (gfrp) (p35).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0042133 neurotransmitter metabolism (TAS)
0006809 nitric oxide biosynthesis (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
GTP cyclohydrolase I feedback regulatory protein (GFRP) in mammals helps regulate the biosynthesis of tetrahydrobiopterin through the feedback inhibition of the rate-limiting enzyme GTP cyclohydrolase I (GTPCHI). Tetrahydrobiopterin is the cofactor required for the hydroxylation of aromatic amino acids. The crystal structure of GFRP reveals that the protein forms a homopentamer . In the presence of phenylalanine.he stimulatory complex consists of a GTPCHI decamer sandwiched by two GFRP pentamers.hich is thought to enhance GTPCHI activity by locking the enzyme in the active state . The structure of GFRP consists of two alpha/beta layers arranged beta(2)-alpha-beta(2)-alpha-beta(2).ith antiparallel beta-sheets in the order 342165.
  IPR009112:GTP cyclohydrolase I, feedback regulatory protein
IPR009112:GFRP 
Evalue:-72.8860549926758 
Location:1-83
SequencesProtein: GFRP_HUMAN (83 aa)
mRNA: NM_005258
Local Annotation
Synapse Ontology
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 44 residues, 38843576-38843706Exon2: 33 residues, 38845316-38845411Exon3: 164 residues, 38846715-38847203Exon4: 2 residues, -Jump to GFRP_HUMAN  
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Loci Cluster (Details)Loci: 2873 38484977-38498355 ~-13K 12090(IVD)(+)Loci: 2874 38550504-38552645 ~-2K 12093(D4ST1)(+)Loci: 2875 38673738-38743829 ~-70K 12099(CASC5)(+)Loci: 2876 38843576-38847203 ~-4K 12107(GCHFR)(+)Loci: 2877 38973919-38983464 ~-10K 12116(VPS18)(+)Loci: 4163 38367401-38387330 ~-20K 12082(PLCB2)(-)Link out to UCSC