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0GFAP_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGFAP
DescriptionGlial fibrillary acidic protein, astrocyte (gfap).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005882 intermediate filament (TAS)
0005200 structural constituent of cytoskeleton (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Intermediate filaments (IF) are proteins which are primordial components of the cytoskeleton and the nuclear envelope. They generally form filamentous structures 8 to 14 nm wide.IF proteins are members of a very large multigene family of proteins which has been subdivided in five major subgroups:Type I: Acidic cytokeratins.Type II: Basic cytokeratins.Type III: Vimentin.esmin.lial fibrillary acidic protein (GFAP).eripherin.nd plasticin.Type IV: Neurofilaments L. and M.lpha-internexin and nestin.Type V: Nuclear lamins A.1.2 and C.All IF proteins are structurally similar in that they consist of: a central rod domain comprising some 300 to 350 residues which is arranged in coiled-coiled alpha-helices.ith at least two short characteristic interruptions; a N-terminal non-helical domain (head) of variable length; and a C-terminal domain (tail) which is also non-helical.nd which shows extreme length variation between different IF proteins.While IF proteins are evolutionary and structurally related.hey have limited sequence homologies except in several regions of the rod domain.
  IPR001664:Intermediate filament protein
This domain represents the N-terminal head region of intermediate filaments. Intermediate filament heads bind DNA . Vimentin heads are able to alter nuclear architecture and chromatin distribution.nd the liberation of heads by HIV-1 protease liberates may play an important role in HIV-1 associated cytopathogenesis and carcinogenesis . Phosphorylation of the head region can affect filament stability . The head has been shown to interaction with the rod domain of the same protein .
  IPR006821:Intermediate filament, DNA-binding region
Keratins are a well known group of intermediate filament proteins. Like actin filaments.eratins are flexible but provide a firm cell skeleton.Unlike actin.owever.o known keratins are associated with motor functions. Approximately 10 keratins form the basis of hair or claw.ith a further 20 found in internal body cavity epithelia. They are alsofound at desmosomes and hemi-desmosomes (cell/cell and cell/matrix contacts respectively) .Type I keratins are a group of acidic intermediate filament proteins thatexist as chains of hetero-dimers with basic type II keratins. Each typeI keratin consists of head-.od- and tail-like structures.he rod beingconstructed from three linked coils: 1A.B and 2. Type I proteins are associated with a number of inherited developmental disorders.uch as baldness.eading of hair.nd skin blistering.
  IPR002957:Keratin, type I
This domain consists of several insect apolipoprotein-III sequences. Exchangeable apolipoproteins constitute a functionally important family of proteins that play critical roles in lipid transport and lipoprotein metabolism. Apolipophorin III (apoLp-III) is a prototypical exchangeable apolipoprotein found in many insect species that functions in transport of diacylglycerol (DAG) from the fat body lipid storage depot to flight muscles in the adult life stage .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011000:Apolipophorin III-like
IPR001664:Filament 
Evalue:-170 
Location:68-376IPR006821:Filament_head 
Evalue:-12.7695512771606 
Location:5-67
SequencesProtein: GFAP_HUMAN (432 aa)
mRNA: NM_002055
Local Annotation
Synapse Ontology
intermediate filaments of the presynaptic compartments. Both microtubles and intermediate filaments represent the main structural scaffold of axons.
sdb:0086 intermediate filaments  (Evidence:keywords)
KO assignmentK05640
  Level 3 annotation:
    glial fibrillary acidic protein
  Level 2 annotation:
    Prion disease
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 589 residues, 40338518-40340282Exon2: 30 residues, 40340957-40341043Exon3: 16 residues, 40343508-40343552Exon4: 75 residues, 40344129-40344350Exon5: 44 residues, 40344565-40344691Exon6: 56 residues, 40346162-40346324Exon7: 34 residues, 40346621-40346717Exon8: 22 residues, 40346921-40346982Exon9: 160 residues, 40347919-40348394Exon10: 2 residues, -Jump to GFAP_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4294 39509646-39556540 ~-47K 15975(HDAC5)(-)Loci: 4295 39682565-39700993 ~-18K 15992(SLC4A1)(-)Loci: 4296 39752520-39757666 ~-5K 15997(-)Loci: 3010 40098011-40104116 ~-6K 16007(+)Loci: 4297 40237112-40263147 ~-26K 16016(GJA7)(-)Loci: 4298 40338518-40348394 ~-10K 16022(GFAP)(-)Loci: 3009 39437557-39441961 ~-4K 15971(NAGS)(+)Link out to UCSC