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0GDF11_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGDF11
DescriptionGrowth/differentiation factor 11 precursor (gdf-11) (bone morphogenetic protein 11).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005125 cytokine activity (NAS)
0007498 mesoderm development (TAS)
0007399 neurogenesis (TAS)
0001501 skeletal development (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The transforming growth factor beta.-terminus (TGFb) domain is present in avariety of proteins which include the transforming growth factor beta.ecapentaplegic proteins and bone morphogenetic proteins. Transforming growthfactor beta is a multifunctional peptide that controls proliferation.ifferentiation and other functions in many cell types. The decapentaplegicprotein acts as an extracellular morphogen responsible for the properdevelopment of the embryonic dorsal hypoderm.or viability of larvae andfor cell viability of the epithelial cells in the imaginal disks. Bonemorphogenetic protein induces cartilage and bone formation and may be responsiblefor epithelial osteogenesis in some organisms.
  IPR001111:Transforming growth factor beta (TGFb), N-terminal
Transforming growth factor-beta (TGF-beta) is a multifunctional peptide that controls proliferation.ifferentiation and other functions in many cell types. TGF-beta-1 is a peptide of 112 amino acid residues derived by proteolytic cleavage from the C-terminal of a precursor protein.A number of proteins are known to be related to TGF-beta-1 . Proteins from the TGF-beta family are only active as homo- or heterodimer; the two chains being linked by a single disulphide bond. From X-ray studies of TGF-beta-2 .t is known that all the other cysteines are involved in intrachain disulphide bonds. As shown in the following schematic representation.here are four disulphide bonds in the TGF-betas and in inhibin beta chains.hile the other members of this family lack the first bond.
  IPR001839:Transforming growth factor beta
IPR001839:TGFB 
Evalue:-47.3279021420643 
Location:313-407IPR001111:TGFb_propeptide 
Evalue:-8.49485015869141 
Location:62-289
SequencesProtein: GDF11_HUMAN (407 aa)
mRNA: NM_005811
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
KO assignmentK05497
  Level 3 annotation:
    growth differentiation factor 8/11
  Level 2 annotation:
    Cytokines
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 160 residues, 54423333-54423812Exon2: 134 residues, 54428636-54429034Exon3: 261 residues, 54429552-54430331Exon4: 2 residues, -Jump to GDF11_HUMAN  
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Loci Cluster (Details)Loci: 2763 54396087-54399754 ~-4K 9024(BLOC1S1)(+)Loci: 2764 54423333-54430331 ~-7K 9030(GDF11)(+)Loci: 2765 54654128-54674745 ~-21K 9056(RAB5B)(+)Loci: 2766 54677309-54685574 ~-8K 9057(SUOX)(+)Loci: 2767 54798296-54802545 ~-4K 9067(+)Loci: 4051 54843395-54869544 ~-26K 9082(SMARCC2)(-)Loci: 4052 54951749-54980442 ~-29K 9095(CS)(-)Loci: 4053 55151003-55168448 ~-17K 9108(GLS2)(-)Loci: 4054 55275981-55316430 ~-40K 9114(BAZ2A)(-)Loci: 4055 55318225-55326119 ~-8K 9115(ATP5B)(-)Loci: 4056 55708568-55730160 ~-22K 9128(MYO1A)(-)Loci: 4050 54364622-54387894 ~-23K 9022(ITGA7)(-)Link out to UCSC