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0GCST_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameAMT
DescriptionAminomethyltransferase, mitochondrial precursor (ec 2.1.2.10) (glycine cleavage system t protein) (gcvt).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
0006546 glycine catabolism (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This is a family of glycine cleavage T-proteins.art of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondriaof eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes.The T-protein is an aminomethyl transferase that catalyses the following reaction:(6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5.0-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein
  IPR006222:Glycine cleavage T protein (aminomethyl transferase)
This entry shows glycine cleavage T-proteins.art of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.
  IPR013977:Glycine cleavage T-protein, C-terminal barrel
This is a subfamily of glycine cleavage T proteins.art of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondriaof eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes.The T-protein is an aminomethyl transferase that catalyses the following reaction:(6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5.0-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein
  IPR006223:Glycine cleavage system T protein
IPR006222:GCV_T 
Evalue:-109.69896697998 
Location:78-291IPR013977:GCV_T_C 
Evalue:-37.8860549926758 
Location:300-392
SequencesProtein: GCST_HUMAN (403 aa)
mRNA: NM_000481
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00605
  Level 3 annotation:
    aminomethyltransferase
  Level 2 annotation:
    Nitrogen metabolism
    Glycine
     serine and threonine metabolism
    One carbon pool by folate
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 314 residues, 49429215-49430155Exon2: 54 residues, 49430254-49430410Exon3: 62 residues, 49431407-49431588Exon4: 50 residues, 49431696-49431842Exon5: 28 residues, 49432146-49432225Exon6: 46 residues, 49432647-49432779Exon7: 29 residues, 49433928-49434009Exon8: 58 residues, 49434540-49434708Exon9: 75 residues, 49434797-49435016Exon10: 2 residues, -Jump to GCST_HUMAN  
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Loci Cluster (Details)Loci: 4601 48530128-48569231 ~-39K 25651(PFKFB4)(-)Loci: 4602 48611435-48622102 ~-11K 25656(UQCRC1)(-)Loci: 4603 48637834-48684985 ~-47K 25658(CELSR3)(-)Loci: 4604 48686283-48698338 ~-12K 25669(NCKIPSD)(-)Loci: 4605 48762098-48860265 ~-98K 25672(-)Loci: 4606 49133551-49145603 ~-12K 25699(LAMB2)(-)Loci: 4607 49429215-49435016 ~-6K 25713(AMT)(-)Loci: 3354 49566925-49683976 ~-117K 25718(BSN)(+)Loci: 4608 49921309-49942261 ~-21K 25739(-)Loci: 4609 50330243-50333903 ~-4K 25774(HYAL2)(-)Loci: 4600 48420266-48441746 ~-21K 25634(PLXNB1)(-)Link out to UCSC