SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0GCSH_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGCSH
DescriptionGlycine cleavage system h protein, mitochondrial precursor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005960 glycine cleavage complex (TAS)
0005739 mitochondrion (TAS)
0004047 aminomethyltransferase activity (TAS)
0006546 glycine catabolism (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/2045809046.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This is a family of glycine cleavage H-proteins.art of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes.A lipoyl group is attached to a completely conserved lysine residue.The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
  IPR002930:Glycine cleavage H-protein
The single hybrid motif has a beta-barrel sandwich hybrid fold.onsisting of a sandwich of half-barrel shaped beta-sheets. This motif is found in biotinyl/lipoyl-carrier proteins and domains.here the biotin and lipoic acid moieties act as covalently attached coenzyme cofactors in enzymes that catalyse metabolic reactions. For example.his motif can be found in the biotinyl domain of Escherichia coli acetyl-CoA carboxylase .rotein H of the glycine cleavage system in Pisum sativum .he ipoyl domain of dihydrolipoamide acetyltransferase.hich is a component of the pyruvate dehydrogenase complex .he lipoyl domain of the 2-oxoglutarate dehydrogenase complex .nd the lipoyl domain f the mitochondrial branched-chain alpha-ketoacid dehydrogenase.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011053:Single hybrid motif
IPR002930:GCV_H 
Evalue:-77.2218475341797 
Location:51-171
SequencesProtein: GCSH_HUMAN (173 aa)
mRNA: NM_004483
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 213 residues, 79673431-79674069Exon2: 46 residues, 79675568-79675700Exon3: 23 residues, 79678706-79678770Exon4: 28 residues, 79681706-79681786Exon5: 83 residues, 79687236-79687481Exon6: 2 residues, -Jump to GCSH_HUMAN  
Tune and view alternative isoforms