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0GCR_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNR3C1
DescriptionGlucocorticoid receptor (gr).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (TAS)
0005759 mitochondrial matrix (TAS)
0005634 nucleus (TAS)
0004883 glucocorticoid receptor activity (TAS)
0005515 protein binding (IPI)
0003700 transcription factor activity (TAS)
0007165 signal transduction (TAS)
0006366 transcription from RNA polymerase II promoter (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Steroid or nuclear hormone receptors (NRs) constitute an important super- family of transcription regulators that are involved in widely diverse physiological functions.ncluding control of embryonic development.ell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and receptors for thyroid hormone.etinoids..5-dihydroxy-vitamin D3 and a variety of other ligands. The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner . In addition to C-terminal ligand-binding domains.hese nuclear receptors contain a highly-conserved.-terminal zinc-finger that mediates specific binding to target DNA sequences.ermed ligand-responsive elements. In the absence of ligand.teroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. NRs are extremely important in medical research. large number of them being implicated in diseases such as cancer.iabetes.ormone resistance syndromes.tc. While several NRs act as ligand-inducible transcription factors.any do not yet have a defined ligand and are accordingly termed "orphan" receptors. During the last decade.ore than 300 NRs have been described.any of which are orphans.hich cannot easily be named due to current nomenclature confusions in the literature. However. new system has recently been introduced in an attempt to rationalise the increasingly complex set of names used to describe superfamily members.The glucocorticoid receptor consists of 3 functional and structural domains: an N-terminal (modulatory) domain; a DNA binding domain that mediates specific binding to target DNA sequences (ligand-responsive elements); and a hormone binding domain. The N-terminal domain is unique to the glucocorticoid receptors; it spans the first 440 residues.nd is primarily responsible for transcriptional activation. The smaller (around 65 residues).ighly-conserved central portion of the protein is the DNA binding domain.hich plays a role in DNA binding specificity.omo- dimerisation and in interactions with other proteins. The hormone binding domain comprises approximately 250 residues at the C-terminus of the receptor. This domain mediates receptor activity via interaction with heat shock proteins and cyclophilins.r with hormone. For more information.ee the GRR resource [http://biochem1.basic-sci.georgetown.edu/GRR/GRR.html].
  IPR001409:Glucocorticoid receptor
Steroid or nuclear hormone receptors constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions.ncluding control of embryonic development.ell differentiation and homeostasis. The receptors function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner. Nuclear hormone receptors consist of a highly conserved DNA-binding domain that recognises specific sequences ().onnected via a linker region to a C-terminal ligand-binding domain. In addition.ertain nuclear hormone receptors have an N-terminal modulatory domain (). The ligand-binding domain acts in response to ligand binding.hich caused a conformational change in the receptor to induce a response.hereby acting as a molecular switch to turn on transcriptional activity . For example.fter binding of the glucocorticoid receptor to the corticosteroid ligand.he receptor is induced to perform functions ranging from nuclear translocation.ligomerisation.ofactor/kinase/transcription factor association.nd DNA binding . The ligand-binding domain is a flexible unit.here the binding of a ligand stabilises its conformation.hich in turn favours coactivator binding to modify receptor activity ; the coactivator can bind to the activator function 2 (AF2) site at the C-terminal end of the ligand-binding domain . The binding of different ligands can alter the conformation of the ligand-binding domain.hich ultimately affects the DNA-binding specificity of the DNA-binding domain. In the absence of ligand.teroid hormone receptors are thought to be weakly associated with nuclear components. This entry represents the C-terminal ligand-binding domain.
  IPR000536:Nuclear hormone receptor, ligand-binding
Steroid or nuclear hormone receptors constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions.ncluding control of embryonic development.ell differentiation and homeostasis. The receptors function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner. Nuclear hormone receptors consist of a highly conserved DNA-binding domain that recognises specific sequences.onnected via a linker region to a C-terminal ligand-binding domain (). In addition.ertain nuclear hormone receptors have an N-terminal modulatory domain (). The DNA-binding domain can elicit either an activating or repressing effect by binding to specific regions of the DNA known as hormone-response elements . These response elements position the receptors.nd the complexes recruited by them.lose to the genes of which transcription is affected. The DNA-binding domains of nuclear receptors consist of two zinc-nucleated modules and a C-terminal extension.here residues in the first zinc module determine the specificity of the DNA recognition and residues in the second zinc module are involved in dimerisation. The DNA-binding domain is furthermore involved in several other functions including nuclear localization.nd interaction with transcription factors and co-activators . This entry represents the two zinc finger modules involved in DNA-binding.
  IPR001628:Nuclear hormone receptor, DNA-binding
Steroid or nuclear hormone receptors (4A nuclear receptor.Rs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions.ncluding control of embryonic development.ell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and receptors for thyroid hormone.etinoids..5-dihydroxy-vitamin D3 and a variety of other ligands . The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner . In addition to C-terminal ligand-binding domains.hese nuclear receptors contain a highly-conserved.-terminal zinc-finger that mediates specific binding to target DNA sequences.ermed ligand-responsive elements. In the absence of ligand.teroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity.NRs are extremely important in medical research. large number of them being implicated in diseases such as cancer.iabetes.ormone resistance syndromes.tc. While several NRs act as ligand-inducible transcription factors.any do not yet have a defined ligand and are accordingly termed orphan receptors. During the last decade.ore than 300 NRs have been described.any of which are orphans.hich cannot easily be named due to current nomenclature confusions in the literature. However. new system has recently been introduced in an attempt to rationalise the increasingly complex set of names used to describe superfamily members.
  IPR001723:Steroid hormone receptor
Steroid or nuclear hormone receptors (4A nuclear receptor.Rs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions.ncluding control of embryonic development.ell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and receptors for thyroid hormone.etinoids..5-dihydroxy-vitamin D3 and a variety of other ligands . The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner . In addition to C-terminal ligand-binding domains.hese nuclear receptors contain a highly-conserved.-terminal zinc-finger that mediates specific binding to target DNA sequences.ermed ligand-responsive elements. In the absence of ligand.teroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity.NRs are extremely important in medical research. large number of them being implicated in diseases such as cancer.iabetes.ormone resistance syndromes.tc. While several NRs act as ligand-inducible transcription factors.any do not yet have a defined ligand and are accordingly termed orphan receptors. During the last decade.ore than 300 NRs have been described.any of which are orphans.hich cannot easily be named due to current nomenclature confusions in the literature. However. new system has recently been introduced in an attempt to rationalise the increasingly complex set of names used to describe superfamily members.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008946:Nuclear receptor, ligand-binding
IPR001409:GCR 
Evalue:-1e+125 
Location:26-401IPR001628:zf-C4 
Evalue:-47.1191864013672 
Location:419-494IPR000536:Hormone_recep 
Evalue:-46.6197891235352 
Location:568-756IPR008946:Str_ncl_receptor 
Evalue:0 
Location:3-17
SequencesProtein: GCR_HUMAN (777 aa)
mRNA: NM_001018077 NM_001024094 U01351
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
calcium-regulated transcription factor
sdb:0215 calcium-regulated transcription factor  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK05771
  Level 3 annotation:
    nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  Level 2 annotation:
    Adipocytokine signaling pathway
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1371 residues, 142637688-142641799Exon2: 54 residues, 142642325-142642483Exon3: 45 residues, 142655217-142655348Exon4: 50 residues, 142658425-142658570Exon5: 95 residues, 142660242-142660521Exon6: 41 residues, 142669854-142669971Exon7: 58 residues, 142673756-142673926Exon8: 401 residues, 142759413-142760610Exon9: 161 residues, 142762968-142763447Exon10: 2 residues, -Jump to GCR_HUMANExon1: 1371 residues, 142637688-142641799Exon2: 54 residues, 142642325-142642483Exon3: 45 residues, 142655217-142655348Exon4: 50 residues, 142658425-142658570Exon5: 95 residues, 142660242-142660521Exon6: 41 residues, 142669854-142669971Exon7: 57 residues, 142673759-142673926Exon8: 401 residues, 142759413-142760610Exon9: 329 residues, 142794289-142795270Exon10: 2 residues, -Jump to GCR_HUMANExon1: 294 residues, 142640919-142641799Exon2: 54 residues, 142642325-142642483Exon3: 45 residues, 142655217-142655348Exon4: 50 residues, 142658425-142658570Exon5: 95 residues, 142660242-142660521Exon6: 41 residues, 142669854-142669971Exon7: 58 residues, 142673756-142673926Exon8: 401 residues, 142759413-142760610Exon9: 161 residues, 142762968-142763447Exon10: 2 residues, -Jump to GCR_HUMAN  
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