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0GCP60_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionGolgi resident protein gcp60 (acyl-coa binding domain containing protein 3) (golgi phosphoprotein 1) (golph1) (golgi complex-associated protein 1) (gocap1) (pbr and pka associated protein 7) (peripherial benzodiazepine receptor associated protein pap7).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
p24 proteins are major membrane components of COPI- and COPII-coated vesicles and are implicated in cargo selectivity of ER to Golgi transport .Multiple members of the p24 family are found in all eukaryotes.rom yeast to mammals. Members of the p24 family are type I membrane proteins with a signal peptide at the amino terminus. lumenal coiled-coil (extracytosolic) domain. single transmembrane domain with conserved amino acids.nd a short cytoplasmic tail. They may be grouped into at least three subfamilies based on primary sequence . One subfamily comprises yeast Emp24p and mammalian p24A. Another subfamily comprises yeast Erv25p and mammalian Tmp21.nd the third subfamily comprises mammalian gp25L proteins.
Acyl-CoA-binding protein (ACBP) is a small (10 Kd) protein that binds medium- and long-chain acyl-CoA esterswith high affinity.nd may act as an intra-cellular carrier of acyl-CoA esters. ACBP has a number of importantphysiological and biochemical functions: it is known as a diazepam binding inhibitor.s a putative neurotransmitter.s a regulator of insulin release from pancreatic cells.nd as a mediator in corticotropin-dependent adrenalsteroidogenesis . It is possible that the protein acts as a neuropeptide that takes partin the modulation of gamma-aminobutyric acid-ergic transmission . The structure of ACBP has been deducedby NMR spectroscopy and has been shown to be a mainly-alpha protein.onsisting of 5 short alpha-helices and 3connecting beta-strands .ACBP is a highly conserved protein of about 90 residues that has been so far found in vertebrates.nsects.lantsand yeast. Other proteins belonging to the ACBP family include mouse endozepine-like peptide (ELP) (gene DBIL5) ; mammalian MA-DBI. transmembrane protein of unknown function which has been found in mammals; and human DRS-1 . protein of unknown function that contains a N-terminal ACBP-like domain and a C-terminal enoyl-CoA isomerase/hydratase domain.
  IPR000582:Acyl-coA-binding protein, ACBP
SequencesProtein: GCP60_HUMAN (527 aa)
mRNA: NM_022735
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
the mechanism by which the restiong potential is held.
sdb:0288 maintain membrane potential  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 714 residues, 224399004-224401145Exon2: 97 residues, 224406658-224406943Exon3: 64 residues, 224408970-224409157Exon4: 60 residues, 224413507-224413682Exon5: 55 residues, 224415854-224416013Exon6: 49 residues, 224419112-224419253Exon7: 49 residues, 224420182-224420324Exon8: 113 residues, 224440713-224441046Exon9: 2 residues, -Jump to GCP60_HUMAN  
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Loci Cluster (Details)Loci: 3865 224399004-224441046 ~-42K 4033(ACBD3)(-)Loci: 2594 224079598-224099883 ~-20K 4021(EPHX1)(+)Link out to UCSC