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0GCH1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGCH1
DescriptionGtp cyclohydrolase i (ec 3.5.4.16) (gtp-ch-i).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003934 GTP cyclohydrolase I activity (TAS)
0042133 neurotransmitter metabolism (TAS)
0006809 nitric oxide biosynthesis (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
GTP cyclohydrolase I () catalyzes the biosynthesis of formic acid and dihydroneopterin triphosphate from GTP. This reaction is the first step in the biosynthesis of tetrahydrofolate in prokaryotes.f tetrahydrobiopterin in vertebrates.nd of pteridine-containing pigments in insects. The comparison of the sequence of the enzyme from bacterial and eukaryotic sources shows that the structure of this enzyme has been extremely well conserved throughout evolution .
  IPR001474:GTP cyclohydrolase I
IPR001474:GTP_cyclohydroI 
Evalue:-55.4202156066895 
Location:128-232
SequencesProtein: GCH1_HUMAN (250 aa)
mRNA: NM_000161
Local Annotation
Synapse Ontology
Typical ecretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of nonpeptide neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
sdb:0094 typical synaptic vesicle  (Evidence:keywords)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords)
KO assignmentK01495
  Level 3 annotation:
    GTP cyclohydrolase I
  Level 2 annotation:
    Folate biosynthesis
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 713 residues, 54378475-54380611Exon2: 30 residues, 54382235-54382320Exon3: 12 residues, 54383566-54383598Exon4: 20 residues, 54396148-54396204Exon5: 38 residues, 54401794-54401904Exon6: 170 residues, 54438788-54439292Exon7: 2 residues, -Jump to GCH1_HUMAN  
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Loci Cluster (Details)Loci: 4133 54684600-54728149 ~-44K 11182(DLG7)(-)Loci: 2839 54807831-54890080 ~-82K 11183(FBXO34)(+)Loci: 2840 55116787-55221047 ~-104K 11187(KTN1)(+)Loci: 4132 54378475-54439292 ~-61K 11172(GCH1)(-)Link out to UCSC