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0GCC2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionGrip and coiled-coil domain-containing protein 2 (golgi coiled coil protein gcc185) (ctcl tumor antigen se1-1) (cll-associated antigen kw- 11).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The GRIP (golgin-97.anBP2alpha.mh1p and p230/golgin-245) domain is found in many large coiled-coil proteins. It has been shown tobe sufficient for targeting to the Golgi. The GRIP domain containsa completely conserved tyrosine residue.
The Rho family GTPases and CDC42 regulate a diverse array of cellularprocesses. Like all members of the Ras superfamily.he Rho proteins cycle between active GTP-bound and inactive GDP-bound conformational states.Activation of Rho proteins through release of bound GDP and subsequentbinding of GTP.s catalyzed by guanine nucleotide exchange factors (GEFs) inthe Dbl family. The proteins encoded by members of the Dbl family share acommon domain.resented in this entry.f about 200 residues (designated the Dbl homology or DH domain)that has been shown to encode a GEF activity specific for a number of Rhofamily members. In addition.ll family members possess a second.hareddomain designated the pleckstrin homology (PH) domain (). Trioand its homolog UNC-73 are unique within the Dbl family insomuch as theyencode two distinct DH/PH domain modules. The PH domain is invariably locatedimmediately C-terminal to the DH domain and this invariant topography suggestsa functional interdependence between these two structural modules. Biochemicaldata have established the role of the conserved DH domain in Rho GTPaseinteraction and activation.nd the role of the tandem PH domain inintracellular targeting and/or regulation of DH domain function. The DH domainof Dbl has been shown to mediate oligomerization that is mostly homophilic innature. In addition to the tandem DH/PH domains Dbl family GEFs containdiverse structural motifs like serine/threonine kinase.BD.DZ.GS.Q.EM.dc25RasGEF.H.H2.H3.F.pectrin or Ig.The DH domain is composed of three structurally conserved regions separated bymore variable regions. It does not share significant sequence homology withother subtypes of small G-protein GEF motifs such as the Cdc25 domain and theSec7 domain.hich specifically interact with Ras and ARFfamily small GTPases.espectively.or with other Rho protein interactivemotifs.ndicating that the Dbl family proteins are evolutionarily unique. TheDH domain is composed of 11 alpha helices that are folded into a flattened.longated alpha-helix bundle in which two of the three conserved regions.onserved region 1 (CR1) and conserved region 3 (CR3).re exposed near thecenter of one surface. CR1 and CR3.ogether with a part of alpha-6 and theDH/PH junction site.onstitute the Rho GTPase interacting pocket.
In prokaryotes.he nucleotide exchange factor GrpE and the chaperone DnaJ are required for nucleotide binding of the molecular chaperone DnaK . The DnaK reaction cycle involves rapid peptide binding and release.hich is dependent upon nucleotide binding. DnaJ accelerates the hydrolysis of ATP by DnaK.hich enables the ADP-bound DnaK to tightly bind peptide. GrpE catalyses the release of ADP from DnaK.hich is required for peptide release. In eukaryotes.rpE is essential for mitochondrial Hsp70 function.owever the cytosolic Hsp70 homologues are GrpE-independent. GrpE binds as a homodimer to the ATPase domain of DnaK.nd may interact with the peptide-binding domain of DnaK. GrpE accomplishes nucleotide exchange by opening the nucleotide-binding cleft of DnaK. GrpE is comprised of two domains.he N-terminal coiled coil domain.hich may facilitate peptide release.nd the C-terminal head domain.hich forms part of the contact surface with the ATPase domain of DnaK. This entry represents the N-terminal coiled-coil domain.
  IPR013805:GrpE nucleotide exchange factor, coiled-coil
SequencesProtein: GCC2_HUMAN (1583 aa)
mRNA: NM_014635 NM_181453
Local Annotation
Synapse Ontology
the mechanism by which the restiong potential is held.
sdb:0288 maintain membrane potential  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 34 residues, 108432067-108432168Exon2: 21 residues, 108432520-108432577Exon3: 30 residues, 108433915-108434000Exon4: 24 residues, 108435286-108435354Exon5: 37 residues, 108451867-108451972Exon6: 824 residues, 108452538-108455004Exon7: 26 residues, 108455714-108455787Exon8: 35 residues, 108458422-108458523Exon9: 35 residues, 108458639-108458738Exon10: 42 residues, 108464584-108464704Exon11: 57 residues, 108465174-108465339Exon12: 37 residues, 108465949-108466054Exon13: 56 residues, 108467036-108467199Exon14: 35 residues, 108468523-108468624Exon15: 28 residues, 108468718-108468796Exon16: 48 residues, 108469398-108469536Exon17: 42 residues, 108470586-108470708Exon18: 61 residues, 108472725-108472902Exon19: 74 residues, 108475460-108475678Exon20: 67 residues, 108478178-108478373Exon21: 48 residues, 108479857-108479997Exon22: 69 residues, 108482440-108482642Exon23: 614 residues, 108490447-108492285Exon24: 2 residues, -Jump to GCC2_HUMANExon1: 34 residues, 108432067-108432168Exon2: 21 residues, 108432520-108432577Exon3: 24 residues, 108435286-108435354Exon4: 37 residues, 108451867-108451972Exon5: 824 residues, 108452538-108455004Exon6: 26 residues, 108455714-108455787Exon7: 35 residues, 108458422-108458523Exon8: 35 residues, 108458639-108458738Exon9: 42 residues, 108464584-108464704Exon10: 57 residues, 108465174-108465339Exon11: 37 residues, 108465949-108466054Exon12: 56 residues, 108467036-108467199Exon13: 35 residues, 108468523-108468624Exon14: 28 residues, 108468718-108468796Exon15: 48 residues, 108469398-108469536Exon16: 42 residues, 108470586-108470708Exon17: 61 residues, 108472725-108472902Exon18: 74 residues, 108475460-108475678Exon19: 67 residues, 108478178-108478373Exon20: 48 residues, 108479857-108479997Exon21: 69 residues, 108482440-108482642Exon22: 614 residues, 108490447-108492285Exon23: 2 residues, -Jump to GCC2_HUMAN  
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Loci Cluster (Details)Loci: 3182 108271526-108292802 ~-21K 21050(SULT1C1)(+)Loci: 3183 108360852-108370702 ~-10K 21052(SULT1C2)(+)Loci: 3184 108432067-108492285 ~-60K 21053(GCC2)(+)Loci: 3181 107969426-107996871 ~-27K 21048(SLC5A7)(+)Link out to UCSC