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0GBRP_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGABRP
DescriptionGamma-aminobutyric-acid receptor pi subunit precursor (gaba(a) receptor).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004890 GABA-A receptor activity (TAS)
Domain Architecture (Details)
InterPro domains assigned to SynO:
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This domain represents four transmembrane helices of a variety of neurotransmitter-gated ion-channels.
  IPR006029:Neurotransmitter-gated ion-channel transmembrane region
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This InterPro entry represents the GABA-A.icotinic.lycine.nd 5HT3 receptors.
  IPR006201:Neurotransmitter-gated ion-channel
InterPro domains unassigned to SynO:
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain . Gamma-aminobutyric acid type A (GABAA) receptors are members of the neurotransmitter ligand-gated ion channels: they mediate neuronal inhibition on binding GABA. The effects of GABA on GABAA receptors are modulated by a range of therapeutically important drugs.ncluding barbiturates.naesthetics and benzodiazepines (BZs) . The BZs are a diverse range of compounds.ncluding widely prescribed drugs.uch as librium and valium.nd their interaction with GABAA receptors provides the most potent pharmacological means of distinguishing different GABAA receptor subtypes. GABAA receptors are pentameric membrane proteins that operate GABA-gated chloride channels . Eight types of receptor subunit have been cloned.ith multiple subtypes within some classes: alpha 1-6.eta 1-4.amma 1-4.elta.psilon.i.ho 1-3 and theta . Subunits are typically 50-60kDa in size and comprise a long N-terminal extracellular domain.ontaining a putative signal peptide and a disulphide-bonded beta structural loop; 4 putative transmembrane (TM) domains; and a large cytoplasmic loop connecting the third and fourth TM domains. Amongst family members.he large cytoplasmic loop displays the most divergence in terms of primary structure.he TM domains showing the highest level of sequence conservation .
  IPR006028:Gamma-aminobutyric acid A receptor
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This entry presents the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.
  IPR006202:Neurotransmitter-gated ion-channel ligand-binding
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain . Gamma-aminobutyric acid type A (GABAA) receptors are members of the neurotransmitter ligand-gated ion channels: they mediate neuronal inhibition on binding GABA. The effects of GABA on GABAA receptors are modulated by a range of therapeutically important drugs.ncluding barbiturates.naesthetics and benzodiazepines (BZs) . The BZs are a diverse range of compounds.ncluding widely prescribed drugs.uch as librium and valium.nd their interaction with GABAA receptors provides the most potent pharmacological means of distinguishing different GABAA receptor subtypes. GABAA receptors are pentameric membrane proteins that operate GABA-gated chloride channels . Eight types of receptor subunit have been cloned.ith multiple subtypes within some classes: alpha 1-6.eta 1-4.amma 1-4.elta.psilon.i.ho 1-3 and theta . Subunits are typically 50-60kDa in size and comprise a long N-terminal extracellular domain.ontaining a putative signal peptide and a disulphide-bonded beta structural loop; 4 putative transmembrane (TM) domains; and a large cytoplasmic loop connecting the third and fourth TM domains. Amongst family members.he large cytoplasmic loop displays the most divergence in terms of primary structure.he TM domains showing the highest level of sequence conservation .The existence of a pi subunit was first reported in 1997.here it wasdetected in a number of human and rat tissues. The subunit shares 30-40%amino acid identity with other members of the GABAA receptor subunit family.The polypeptide is found in several peripheral tissues.ncluding theuterus.here its function appears to be related to tissue contractility: pisubunits can co-assemble with other GABAA receptor subunits to formrecombinant receptors with altered sensitivity to pregnenalone .
  IPR008100:Gamma-aminobutyric-acid A receptor pi subunit
IPR006202:Neur_chan_LBD 
Evalue:-63.5850257873535 
Location:41-242IPR006029:Neur_chan_memb 
Evalue:-25.8538722991943 
Location:249-329IPR008100:GABAARPI 
Evalue:0 
Location:1-25IPR006028:GABAARECEPTR 
Evalue:0 
Location:417-437IPR008100:GABAARPI 
Evalue:0 
Location:386-400
SequencesProtein: GBRP_HUMAN (440 aa)
mRNA: NM_014211
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords,domains)
this kind of receptor usually locates at the postsynaptic plasma membranous region.
sdb:0109 ionotropic receptor  (Evidence:keywords,domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
?
sdb:0305 binding to postsynaptic receptor and internization  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
?
sdb:0334 inhibitory postsynapstic component  (Evidence:keywords,domains)
KO assignmentK05189
  Level 3 annotation:
    gamma-aminobutyric acid (GABA) A receptor, pi
  Level 2 annotation:
    Neuroactive ligand-receptor interaction
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 39 residues, 170143342-170143456Exon2: 33 residues, 170148155-170148250Exon3: 41 residues, 170148710-170148829Exon4: 24 residues, 170153812-170153880Exon5: 74 residues, 170154789-170155007Exon6: 29 residues, 170157047-170157130Exon7: 48 residues, 170165297-170165435Exon8: 53 residues, 170168181-170168334Exon9: 64 residues, 170169149-170169337Exon10: 698 residues, 170171537-170173626Exon11: 2 residues, -Jump to GBRP_HUMAN  
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Loci Cluster (Details)Loci: 3508 169863625-170096212 ~-233K 29918(KCNIP1)(+)Loci: 3509 170143342-170173626 ~-30K 29921(GABRP)(+)Loci: 4753 169737744-169749216 ~-11K 29917(KCNMB1)(-)Link out to UCSC