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0GBLP_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGNB2L1
DescriptionGuanine nucleotide-binding protein beta subunit 2-like 1 (guanine nucleotide-binding protein beta subunit-like protein 12.3) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005080 protein kinase C binding (ISS)
0005102 receptor binding (NAS)
0007205 protein kinase C activation (ISS)
0007165 signal transduction (ISS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs.ften terminating in a Trp-Asp (W-D) dipeptide. WD-containing proteins have 4 to 16 repeating units.ll of which are thought to form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. The underlying common function of all WD-repeat proteins is coordinating multi-protein complex assemblies.here the repeating units serve as a rigid scaffold for protein interactions. The specificity of the proteins is determined by the sequences outside the repeats themselves. Examples of such complexes are G proteins (beta subunit is a beta-propeller).AFII transcription factor.nd E3 ubiquitin ligase .
  IPR001680:WD-40 repeat
The WD40 motif is found in a multitude of eukaryotic proteins involved in a variety of cellular processes . Repeated WD40 motifs act as a site for protein-protein interaction.nd proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. In Arabidopsis sp..everal WD40-containig proteins act as key regulators of plant-specific developmental events. WD40 repeats usually assume a 7-8 bladed beta-propeller fold.ut proteins have been found with 4 to 16 repeated units.The structures of several WD40 repeat-containing proteins have been determined.ncluding the beta-1 subunit of the signal-transducing G protein heterotrimer.he C-terminal domain of yeast Tup1.he C-terminal domain of Groucho/tle1.he Cdc4 propeller domain.he bovine Arp2/3 complex 41 kDa subunit ARPC1.nd actin interacting protein 1. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011046:WD40-like
IPR001680:WD40 
Evalue:-13 
Location:93-132IPR001680:WD40 
Evalue:-10.4685211181641 
Location:52-90IPR001680:WD40 
Evalue:-9.53760242462158 
Location:134-177IPR001680:WD40 
Evalue:-9.09151458740234 
Location:180-219IPR001680:WD40 
Evalue:-8.72124671936035 
Location:3-43IPR001680:WD40 
Evalue:-4.10237312316895 
Location:270-310IPR001680:WD40 
Evalue:-3.67778062820435 
Location:222-259
SequencesProtein: GBLP_HUMAN (317 aa)
mRNA: AY336089 CR609042 NM_006098
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 39 residues, 180596533-180596648Exon2: 39 residues, 180597214-180597325Exon3: 49 residues, 180597704-180597845Exon4: 39 residues, 180598672-180598783Exon5: 34 residues, 180599092-180599188Exon6: 51 residues, 180601097-180601245Exon7: 59 residues, 180601779-180601951Exon8: 73 residues, 180603297-180603512Exon9: 2 residues, -Jump to GBLP_HUMANExon1: 24 residues, 180596578-180596648Exon2: 39 residues, 180597214-180597325Exon3: 49 residues, 180597704-180597845Exon4: 39 residues, 180598672-180598783Exon5: 34 residues, 180599092-180599188Exon6: 51 residues, 180601097-180601245Exon7: 60 residues, 180601775-180601951Exon8: 39 residues, 180603297-180603409Exon9: 2 residues, -Jump to GBLP_HUMANExon1: 23 residues, 180596582-180596648Exon2: 39 residues, 180597214-180597325Exon3: 49 residues, 180597704-180597845Exon4: 39 residues, 180598672-180598783Exon5: 34 residues, 180599092-180599188Exon6: 52 residues, 180601097-180601248Exon7: 58 residues, 180601782-180601951Exon8: 69 residues, 180603297-180603500Exon9: 2 residues, -Jump to GBLP_HUMAN  
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