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0GANAB_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGANAB
DescriptionNeutral alpha-glucosidase ab precursor (ec 3.2.1.84) (glucosidase ii alpha subunit).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (IPI)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates.r between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosylhydrolases.ased on sequence similarity.as led to the definition of 85 different families . This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site . Because the fold of proteins is better conserved than their sequences.ome of the families can be grouped in clans.Glycoside hydrolase family 31 comprises enzymes with several known activities; alpha-glucosidase ().lpha-galactosidase (); glucoamylase ().ucrase-isomaltase () (); alpha-xylosidase (); alpha-glucan lyase (). Glycoside hydrolase family 31 groups a number of glycosyl hydrolases on the basis of sequencesimilarities An aspartic acid has been implicated in the catalytic activity of sucrase.somaltase.nd lysosomal alpha-glucosidase.
  IPR000322:Glycoside hydrolase, family 31
IPR000322:Glyco_hydro_31 
Evalue:-240.522872924805 
Location:365-810
SequencesProtein: GANAB_HUMAN (944 aa)
mRNA: NM_198334 NM_198335
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 366 residues, 62148876-62149972Exon2: 35 residues, 62150112-62150213Exon3: 39 residues, 62150382-62150495Exon4: 40 residues, 62150618-62150732Exon5: 27 residues, 62150907-62150982Exon6: 27 residues, 62151095-62151172Exon7: 20 residues, 62151336-62151392Exon8: 83 residues, 62152816-62153060Exon9: 36 residues, 62153241-62153343Exon10: 34 residues, 62153635-62153732Exon11: 50 residues, 62153861-62154005Exon12: 28 residues, 62154244-62154324Exon13: 44 residues, 62154426-62154553Exon14: 80 residues, 62154648-62154884Exon15: 53 residues, 62155077-62155231Exon16: 62 residues, 62156612-62156793Exon17: 34 residues, 62157052-62157149Exon18: 31 residues, 62157231-62157319Exon19: 25 residues, 62157492-62157562Exon20: 24 residues, 62158357-62158423Exon21: 62 residues, 62158868-62159048Exon22: 44 residues, 62163030-62163158Exon23: 38 residues, 62163406-62163515Exon24: 37 residues, 62163674-62163779Exon25: 25 residues, 62170609-62170680Exon26: 2 residues, -Jump to GANAB_HUMANExon1: 365 residues, 62148878-62149972Exon2: 35 residues, 62150112-62150213Exon3: 39 residues, 62150382-62150495Exon4: 40 residues, 62150618-62150732Exon5: 27 residues, 62150907-62150982Exon6: 27 residues, 62151095-62151172Exon7: 23 residues, 62151336-62151401Exon8: 83 residues, 62152816-62153060Exon9: 36 residues, 62153241-62153343Exon10: 34 residues, 62153635-62153732Exon11: 50 residues, 62153861-62154005Exon12: 28 residues, 62154244-62154324Exon13: 44 residues, 62154426-62154553Exon14: 80 residues, 62154648-62154884Exon15: 53 residues, 62155077-62155231Exon16: 62 residues, 62156612-62156793Exon17: 34 residues, 62157052-62157149Exon18: 31 residues, 62157231-62157319Exon19: 25 residues, 62157492-62157562Exon20: 62 residues, 62158868-62159048Exon21: 44 residues, 62163030-62163158Exon22: 38 residues, 62163406-62163515Exon23: 37 residues, 62163674-62163779Exon24: 25 residues, 62170609-62170680Exon25: 2 residues, -Jump to GANAB_HUMAN  
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Loci Cluster (Details)Loci: 2668 62137198-62139162 ~-2K 6915(ROM1)(+)Loci: 3955 62148876-62170680 ~-22K 6917(GANAB)(-)Loci: 2669 62252159-62262681 ~-11K 6930(+)Loci: 3956 62330945-62356116 ~-25K 6938(STX5A)(-)Loci: 2670 62380093-62412928 ~-33K 6943(SLC3A2)(+)Loci: 3957 62432727-62445588 ~-13K 6949(CHRM1)(-)Loci: 3954 62117250-62125879 ~-9K 6910(MTA2)(-)Link out to UCSC