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0GALR1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGALR1
DescriptionGalanin receptor type 1 (gal1-r) (galr1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (TAS)
0005886 plasma membrane (TAS)
0004966 galanin receptor activity (TAS)
0007586 digestion (TAS)
0007194 negative regulation of adenylate cyclase ac... (TAS)
0007218 neuropeptide signaling pathway (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Galanin is a neurotransmitter in the peripheral and central nervous systemswith a wide spectrum of activity. In the periphery.alanin inhibitsglucose-induced insulin release and may be the sympathetic mediator of thiseffect during stress. In the CNS.t inhibits firing of locus coeruleuscells.s synergistic with opiates in inducing analgesia at the level ofthe spinal cord.nd stimulates feeding behaviour and release of growthhormone . Its ability to inhibit acetylcholine release in the hippocampus has led to the suggestion that galanin antagonists may be of use inthe treatment of Alzheimers disease.The distribution of galanin receptors in the CNS corresponds to that ofgalanin.ith high levels in locus coeruleus.pinal cord.ypothalamus.entral hippocampus and striatum. In the periphery.alanin receptors arefound in smooth muscle and in pancreas. They are also expressed in somehypothalamic tumours. Inhibition of adenylyl cyclase and Ca2+ channels.nd activation of K+ channels is effected via a pertussis-toxin-sensitiveG-protein.robably of the Gi/Go class .
  IPR000405:Galanin receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .G-protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal matingpheromone receptors.nd the metabotropic glutamate receptor family.The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guaninenucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices .Galanin is a neurotransmitter in the peripheral and central nervous systemswith a wide spectrum of activity. In the periphery.alanin inhibitsglucose-induced insulin release and may be the sympathetic mediator of thiseffect during stress. In the CNS.t inhibits firing of locus coeruleuscells.s synergistic with opiates in inducing analgesia at the level ofthe spinal cord.nd stimulates feeding behaviour and release of growthhormone . Its ability to inhibit acetylcholine release in the hippocampus has led to the suggestion that galanin antagonists may be of use in the treatment of Alzheimers disease.Galanin receptors are expressed abundantly in a wide range of CNS andperipheral tissues.irroring the distribution of galanin. Three receptorsubtypes have been identified.iffering from one another in terms of theirexpression patterns.ffinity for various peptide analogues and G-protein-coupling specificity . All are capable of activating K+ channels by coupling to G-proteins of the Gi/Go class .The galanin 1 receptor subtype is expressed at significant levels in regionsof the brain and spinal cord including the hypothalamus.mygdala.ippocampus.halamus and brainstem. It has also been detected throughoutthe length of the human gastro-intestinal tract . Activation of the receptor by galanin leads to decreased cAMP levels.pening of inwardlyrectifying K+ channels and stimulation of MAP kinase activity.ndicatingcoupling to a Gi-protein. The receptor does not appear to couple to Go-.q-or Gs-proteins .
  IPR003906:Galanin 1 receptor
IPR000276:7tm_1 
Evalue:-75.6020584106445 
Location:50-303IPR003906:GALANIN1R 
Evalue:0 
Location:1-22IPR003906:GALANIN1R 
Evalue:0 
Location:24-37IPR003906:GALANIN1R 
Evalue:0 
Location:337-349
SequencesProtein: GALR1_HUMAN (349 aa)
mRNA: NM_001480
Local Annotation
Synapse Ontology
?
sdb:0219 GPCR mediated signaling  (Evidence:domains)
KO assignmentK04230
  Level 3 annotation:
    galanin receptor 1
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 480 residues, 73090720-73092158Exon2: 24 residues, 73097101-73097167Exon3: 519 residues, 73109528-73111081Exon4: 2 residues, -Jump to GALR1_HUMAN  
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