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0GABT_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameABAT
Description4-aminobutyrate aminotransferase, mitochondrial precursor (ec 2.6.1.19) ((s)-3-amino-2-methylpropionate transaminase) (ec 2.6.1.22) (gamma-amino-n-butyrate transaminase) (gaba transaminase) (gaba aminotransferase) (gaba-at) (gaba-t) (l-aibat).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005759 mitochondrial matrix (NAS)
0003867 4-aminobutyrate transaminase activity (NAS)
0007268 synaptic transmission (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Aminotransferases share certain mechanistic features with other pyridoxalphosphate-dependent enzymes.uch as the covalent binding of the pyridoxalphosphate group to a lysine residue. On the basis of sequence similarity.hese various enzymes can be grouped into subfamilies. One of these.alled class-III.ncludes acetylornithine aminotransferase ().hich catalyzes the transfer of an amino group from acetylornithine to alpha-ketoglutarate.ielding N-acetyl-glutamic-5-semi-aldehyde and glutamic acid; ornithine aminotransferase ().hich catalyzes the transfer of an amino group from ornithine to alpha-ketoglutarate.ielding glutamic-5-semi-aldehyde and glutamic acid; omega-amino acid--pyruvate aminotransferase ().hich catalyzes transamination between a variety of omega-amino acids.ono- and diamines.nd pyruvate; 4-aminobutyrate aminotransferase () (GABA transaminase).hich catalyzes the transfer of an amino group from GABA to alpha-ketoglutarate.ielding succinate semialdehyde and glutamic acid; DAPA aminotransferase (). bacterial enzyme (bioA).hich catalyzes an intermediate step in the biosynthesis of biotin.he transamination of 7-keto-8-aminopelargonic acid to form 7.-diaminopelargonic acid; 2.-dialkylglycine decarboxylase (). Pseudomonas cepacia enzyme (dgdA) that catalyzes the decarboxylating amino transfer of2.-dialkylglycine and pyruvate to dialkyl ketone.lanine and carbon dioxide; glutamate-1-semialdehyde aminotransferase () (GSA); Bacillus subtilis aminotransferases yhxA and yodT; Haemophilus influenzae aminotransferase HI0949; and Caenorhabditis elegans aminotransferase T01B11.2.
  IPR005814:Aminotransferase class-III
4-aminobutyrate aminotransferase eukaryotic () is a class III pyridoxal-phosphate-dependent aminotransferase. The enzyme catalyses the conversion of 4-aminobutanoate and 2-oxoglutarate into succinate semialdehyde and L-glutamate. The degree of sequence difference between this set and known bacterial examples is greater than the distance between either set the most similar enzyme with distinct function.nd so the prokaryotic and eukaryotic sets have been placed into separate families. This family describes known eukaryotic examples of the enzyme. Alternate names include GABA transaminase.amma-amino-N-butyrate transaminase.nd beta-alanine--oxoglutarate aminotransferase.
  IPR004631:4-aminobutyrate aminotransferase eukaryotic
IPR005814:Aminotran_3 
Evalue:-185.036209106445 
Location:76-446
SequencesProtein: GABT_HUMAN (500 aa)
mRNA: NM_020686
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords)
KO assignmentK00823
  Level 3 annotation:
    4-aminobutyrate aminotransferase
  Level 2 annotation:
    Propanoate metabolism
    Butanoate metabolism
    Glutamate metabolism
    Alanine and aspartate metabolism
    beta-Alanine metabolism
K07250
  Level 3 annotation:
    (S)-3-amino-2-methylpropionate transaminase
  Level 2 annotation:
    Valine
     leucine and isoleucine degradation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 42 residues, 8675945-8676069Exon2: 39 residues, 8737056-8737167Exon3: 34 residues, 8747358-8747456Exon4: 12 residues, 8749465-8749495Exon5: 41 residues, 8751779-8751897Exon6: 18 residues, 8759114-8759164Exon7: 29 residues, 8765426-8765507Exon8: 33 residues, 8766095-8766188Exon9: 23 residues, 8767565-8767628Exon10: 23 residues, 8769550-8769614Exon11: 51 residues, 8770182-8770331Exon12: 48 residues, 8774137-8774275Exon13: 58 residues, 8776247-8776415Exon14: 51 residues, 8777701-8777848Exon15: 39 residues, 8780836-8780948Exon16: 1090 residues, 8782666-8785932Exon17: 2 residues, -Jump to GABT_HUMAN  
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Loci Cluster (Details)Loci: 2924 8799228-8850689 ~-51K 13485(PMM2)(+)Loci: 2923 8675945-8785932 ~-110K 13482(ABAT)(+)Link out to UCSC