SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0GABR1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGABBR1
DescriptionGamma-aminobutyric acid type b receptor, subunit 1 precursor (gaba-b receptor 1) (gaba-b-r1) (gb1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0004965 GABA-B receptor activity (TAS)
0007214 gamma-aminobutyric acid signaling pathway (TAS)
0007194 negative regulation of adenylate cyclase ac... (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/1145760914.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+ intracellular signalling pathway . The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these and receptors of the rhodopsin-type family: the metabotropic glutamate receptors thus bear their own distinctive 7TM signature. This 7TM signature is also shared by the calcium-sensing receptors.nd GABA (gamma-amino-butyric acid) type B (GABA(B)) receptors.GABA is the principal inhibitory neurotransmitterin the brain.nd signals through ionotropic (GABA(A)/GABA(C)) andmetabotropic (GABA(B)) receptor systems. The GABA(B) receptors havebeen cloned.nd photoaffinity labelling experiments suggest that theycorrespond to two highly conserved receptor forms in the vertebrate nervoussystem .GABA(B) receptors are involved in the fine tuning of inhibitory synaptictransmission . Presynaptic receptors inhibit neurotransmitter release bydown-regulating high-voltage activated Ca2+ channels.hile postsynapticreceptors decrease neuronal excitability by activating a prominent inwardlyrectifying K+ (Kir) conductance that underlies the late inhibitory postsynaptic potentials . GABA(B) receptors negatively couple to adenylylcyclase and show sequence similarity to the metabotropic receptors for theexcitatory neurotransmitter L-glutamate.
  IPR002455:Metabotropic gamma-aminobutyric acid receptor, type B
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+ intracellular signalling pathway . The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these and receptors of the rhodopsin-type family: the metabotropic glutamate receptors thus bear their own distinctive 7TM signature. This 7TM signature is also shared by the calcium-sensing receptors.nd GABA (gamma-amino-butyric acid) type B (GABA(B)) receptors.
  IPR000337:GPCR, family 3, metabotropic glutamate receptor-like
This describes a ligand binding domain and includes extracellular ligand binding domains of a wide range of receptors.s well as the bacterial amino acid binding proteins of known structure .
  IPR001828:Extracellular ligand-binding receptor
Sushi domains are also known as Complement control protein (CCP) modules.r short consensus repeats (SCR).xist in a widevariety of complement and adhesion proteins. The structure is known for this domain.t is based on a beta-sandwich arrangement; oneface made up of three beta-strands hydrogen-bonded to form a triple-stranded region at itscentre and the other face formed from two separate beta-strands .CD21 (also called C3d receptor.R2.pstein Barr virus receptor or EBV-R) is the receptor for EBV and for C3d.3dg and iC3b. Complement components may activate B cells through CD21. CD21 is part of a large signal-transduction complex that also involves CD19.D81.nd Leu13. Some of the proteins in this group are responsible for the molecular basis of the blood group antigens.urface markers on the outside of the red blood cell membrane. Most of these markers are proteins.ut some are carbohydrates attached to lipids or proteins [Reid M.E..omas-Francis C. The Blood Group Antigen FactsBook Academic Press.ondon / San Diego.1997)]. Complement decay-accelerating factor (Antigen CD55) belongs to the Cromer blood group system and is associated with Cr(a).r(a).s(a).c(a/b/c).d(a).ES(a/b).FC and UMC antigens. Complement receptor type 1 (C3b/C4b receptor) (Antigen CD35) belongs to the Knops blood group system and is associated with Kn(a/b).cC(a).l(a) and Yk(a) antigens.CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at http://www.ncbi.nlm.nih.gov/PROW/guide/45277084.htm
  IPR000436:Sushi/SCR/CCP
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+ intracellular signalling pathway . The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these and receptors of the rhodopsin-type family: the metabotropic glutamate receptors thus bear their own distinctive 7TM signature. This 7TM signature is also shared by the calcium-sensing receptors.nd GABA (gamma-amino-butyric acid) type B (GABA(B)) receptors.GABA is the principal inhibitory neurotransmitterin the brain.nd signals through ionotropic (GABA(A)/GABA(C)) andmetabotropic (GABA(B)) receptor systems. The GABA(B) receptors havebeen cloned.nd photoaffinity labelling experiments suggest that theycorrespond to two highly conserved receptor forms in the vertebrate nervoussystem .GABA(B) receptors are involved in the fine tuning of inhibitory synaptictransmission . Presynaptic receptors inhibit neurotransmitter release bydown-regulating high-voltage activated Ca2+ channels.hile postsynapticreceptors decrease neuronal excitability by activating a prominent inwardlyrectifying K+ (Kir) conductance that underlies the late inhibitory postsynaptic potentials . GABA(B) receptors negatively couple to adenylylcyclase and show sequence similarity to the metabotropic receptors for theexcitatory neurotransmitter L-glutamate.Neurophysiological and pharmacological studies point to a major role of theGABA(B) receptor in the epileptogenesis of absence seizures . Using insitu hybridisation.he gene encoding the human GABA(B) type 1 receptor hasbeen mapped to chromosome 6p21.3.n the vicinity of a susceptibility locus(EJM1) for idiopathic generalised epilepsies.dentifying a candidate genefor inherited forms of epilepsy .
  IPR002456:Metabotropic gamma-aminobutyric acid receptor, type B1
IPR000337:7tm_3 
Evalue:-104.677780151367 
Location:595-867IPR001828:ANF_receptor 
Evalue:-88.8239059448242 
Location:187-546IPR000436:CCP 
Evalue:-9.53760200210104 
Location:100-157IPR002456:GABAB1RECPTR 
Evalue:0 
Location:165-186IPR002456:GABAB1RECPTR 
Evalue:0 
Location:886-904IPR000337:G_PROTEIN_RECEP_F3_3 
Evalue:0 
Location:0-0IPR000436:CCP 
Evalue:0.939519252618618 
Location:30-96
SequencesProtein: GABR1_HUMAN (961 aa)
mRNA: NM_001470
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords,domains)
translating calcium signal into the corresponding biological event. Calcium may come from outside of the cell or subcelluar organelle to increase the cytosolic concentration.
sdb:0218 calcium sigal  (Evidence:keywords,domains)
?
sdb:0219 GPCR mediated signaling  (Evidence:keywords,domains)
?
sdb:0223 transmitter release  (Evidence:keywords,domains)
?
sdb:0265 cAMP mediated STP  (Evidence:keywords,domains)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
?
sdb:0334 inhibitory postsynapstic component  (Evidence:keywords,domains)
KO assignmentK04615
  Level 3 annotation:
    gamma-aminobutyric acid (GABA) B receptor, 1
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 497 residues, 1025321-1026809Exon2: 50 residues, 1027586-1027730Exon3: 45 residues, 1027952-1028081Exon4: 44 residues, 1028661-1028789Exon5: 33 residues, 1029483-1029577Exon6: 38 residues, 1029989-1030097Exon7: 41 residues, 1030194-1030311Exon8: 46 residues, 1031693-1031826Exon9: 52 residues, 1032321-1032472Exon10: 28 residues, 1034016-1034094Exon11: 23 residues, 1035643-1035707Exon12: 83 residues, 1036335-1036578Exon13: 66 residues, 1044194-1044386Exon14: 24 residues, 1044845-1044911Exon15: 36 residues, 1045197-1045299Exon16: 59 residues, 1046398-1046569Exon17: 47 residues, 1046983-1047118Exon18: 55 residues, 1050579-1050740Exon19: 9 residues, 1052180-1052201Exon20: 64 residues, 1053551-1053737Exon21: 70 residues, 1054489-1054693Exon22: 30 residues, 1055394-1055479Exon23: 80 residues, 1055943-1056177Exon24: 2 residues, -Jump to GABR1_HUMANExon1: 497 residues, 1025321-1026809Exon2: 50 residues, 1027586-1027730Exon3: 45 residues, 1027952-1028081Exon4: 44 residues, 1028661-1028789Exon5: 33 residues, 1029483-1029577Exon6: 38 residues, 1029989-1030097Exon7: 41 residues, 1030194-1030311Exon8: 46 residues, 1031693-1031826Exon9: 52 residues, 1032321-1032472Exon10: 28 residues, 1034016-1034094Exon11: 23 residues, 1035643-1035707Exon12: 83 residues, 1036335-1036578Exon13: 66 residues, 1044194-1044386Exon14: 24 residues, 1044845-1044911Exon15: 36 residues, 1045197-1045299Exon16: 59 residues, 1046398-1046569Exon17: 47 residues, 1046983-1047118Exon18: 55 residues, 1050579-1050740Exon19: 9 residues, 1052180-1052201Exon20: 70 residues, 1054489-1054693Exon21: 30 residues, 1055394-1055479Exon22: 80 residues, 1055943-1056177Exon23: 2 residues, -Jump to Q5STL7_HUMANExon1: 497 residues, 1025321-1026809Exon2: 50 residues, 1027586-1027730Exon3: 45 residues, 1027952-1028081Exon4: 44 residues, 1028661-1028789Exon5: 33 residues, 1029483-1029577Exon6: 38 residues, 1029989-1030097Exon7: 41 residues, 1030194-1030311Exon8: 46 residues, 1031693-1031826Exon9: 52 residues, 1032321-1032472Exon10: 28 residues, 1034016-1034094Exon11: 23 residues, 1035643-1035707Exon12: 83 residues, 1036335-1036578Exon13: 66 residues, 1044194-1044386Exon14: 24 residues, 1044845-1044911Exon15: 36 residues, 1045197-1045299Exon16: 59 residues, 1046398-1046569Exon17: 47 residues, 1046983-1047118Exon18: 163 residues, 1050579-1051064Exon19: 2 residues, -Jump to Q5STL7_HUMANLoci index, Chromosomal location, Length, Possible relational loci clusterExon1: 497 residues, 827283-828771Exon2: 50 residues, 829548-829692Exon3: 45 residues, 829914-830043Exon4: 44 residues, 830623-830751Exon5: 33 residues, 831445-831539Exon6: 38 residues, 831951-832059Exon7: 41 residues, 832156-832273Exon8: 46 residues, 833655-833788Exon9: 52 residues, 834283-834434Exon10: 28 residues, 835978-836056Exon11: 23 residues, 837605-837669Exon12: 83 residues, 838297-838540Exon13: 66 residues, 846156-846348Exon14: 24 residues, 846807-846873Exon15: 36 residues, 847159-847261Exon16: 59 residues, 848360-848531Exon17: 47 residues, 848945-849080Exon18: 55 residues, 852541-852702Exon19: 9 residues, 854142-854163Exon20: 64 residues, 855513-855699Exon21: 70 residues, 856451-856655Exon22: 30 residues, 857356-857441Exon23: 80 residues, 857905-858139Exon24: 2 residues, -Jump to GABR1_HUMANExon1: 497 residues, 827283-828771Exon2: 50 residues, 829548-829692Exon3: 45 residues, 829914-830043Exon4: 44 residues, 830623-830751Exon5: 33 residues, 831445-831539Exon6: 38 residues, 831951-832059Exon7: 41 residues, 832156-832273Exon8: 46 residues, 833655-833788Exon9: 52 residues, 834283-834434Exon10: 28 residues, 835978-836056Exon11: 23 residues, 837605-837669Exon12: 83 residues, 838297-838540Exon13: 66 residues, 846156-846348Exon14: 24 residues, 846807-846873Exon15: 36 residues, 847159-847261Exon16: 59 residues, 848360-848531Exon17: 47 residues, 848945-849080Exon18: 55 residues, 852541-852702Exon19: 9 residues, 854142-854163Exon20: 70 residues, 856451-856655Exon21: 30 residues, 857356-857441Exon22: 80 residues, 857905-858139Exon23: 2 residues, -Jump to Q5STL7_HUMANExon1: 497 residues, 827283-828771Exon2: 50 residues, 829548-829692Exon3: 45 residues, 829914-830043Exon4: 44 residues, 830623-830751Exon5: 33 residues, 831445-831539Exon6: 38 residues, 831951-832059Exon7: 41 residues, 832156-832273Exon8: 46 residues, 833655-833788Exon9: 52 residues, 834283-834434Exon10: 28 residues, 835978-836056Exon11: 23 residues, 837605-837669Exon12: 83 residues, 838297-838540Exon13: 66 residues, 846156-846348Exon14: 24 residues, 846807-846873Exon15: 36 residues, 847159-847261Exon16: 59 residues, 848360-848531Exon17: 47 residues, 848945-849080Exon18: 163 residues, 852541-853026Exon19: 2 residues, -Jump to Q5STL7_HUMANLoci index, Chromosomal location, Length, Possible relational loci clusterExon1: 497 residues, 29677984-29679472Exon2: 50 residues, 29680249-29680393Exon3: 45 residues, 29680615-29680744Exon4: 44 residues, 29681324-29681452Exon5: 33 residues, 29682146-29682240Exon6: 38 residues, 29682652-29682760Exon7: 41 residues, 29682857-29682974Exon8: 46 residues, 29684356-29684489Exon9: 52 residues, 29684984-29685135Exon10: 28 residues, 29686679-29686757Exon11: 23 residues, 29688306-29688370Exon12: 83 residues, 29688998-29689241Exon13: 66 residues, 29696856-29697048Exon14: 24 residues, 29697507-29697573Exon15: 36 residues, 29697859-29697961Exon16: 59 residues, 29699060-29699231Exon17: 47 residues, 29699645-29699780Exon18: 55 residues, 29703241-29703402Exon19: 9 residues, 29704842-29704863Exon20: 64 residues, 29706213-29706399Exon21: 70 residues, 29707151-29707355Exon22: 30 residues, 29708056-29708141Exon23: 80 residues, 29708605-29708839Exon24: 2 residues, -Jump to GABR1_HUMANExon1: 497 residues, 29677984-29679472Exon2: 50 residues, 29680249-29680393Exon3: 45 residues, 29680615-29680744Exon4: 44 residues, 29681324-29681452Exon5: 33 residues, 29682146-29682240Exon6: 38 residues, 29682652-29682760Exon7: 41 residues, 29682857-29682974Exon8: 46 residues, 29684356-29684489Exon9: 52 residues, 29684984-29685135Exon10: 28 residues, 29686679-29686757Exon11: 23 residues, 29688306-29688370Exon12: 83 residues, 29688998-29689241Exon13: 66 residues, 29696856-29697048Exon14: 24 residues, 29697507-29697573Exon15: 36 residues, 29697859-29697961Exon16: 59 residues, 29699060-29699231Exon17: 47 residues, 29699645-29699780Exon18: 55 residues, 29703241-29703402Exon19: 9 residues, 29704842-29704863Exon20: 70 residues, 29707151-29707355Exon21: 30 residues, 29708056-29708141Exon22: 80 residues, 29708605-29708839Exon23: 2 residues, -Jump to Q5STL7_HUMANExon1: 497 residues, 29677984-29679472Exon2: 50 residues, 29680249-29680393Exon3: 45 residues, 29680615-29680744Exon4: 44 residues, 29681324-29681452Exon5: 33 residues, 29682146-29682240Exon6: 38 residues, 29682652-29682760Exon7: 41 residues, 29682857-29682974Exon8: 46 residues, 29684356-29684489Exon9: 52 residues, 29684984-29685135Exon10: 28 residues, 29686679-29686757Exon11: 23 residues, 29688306-29688370Exon12: 83 residues, 29688998-29689241Exon13: 66 residues, 29696856-29697048Exon14: 24 residues, 29697507-29697573Exon15: 36 residues, 29697859-29697961Exon16: 59 residues, 29699060-29699231Exon17: 47 residues, 29699645-29699780Exon18: 163 residues, 29703241-29703726Exon19: 2 residues, -Jump to Q5STL7_HUMAN  
Loci Cluster (Details)Loci: 3568 1080116-1095456 ~-15K 32266(MOG)(+)Loci: 4846 1569907-1577353 ~-7K 32295(TRIM10)(-)Loci: 3569 1743552-1760022 ~-16K 32299(+)Loci: 4847 2116160-2131531 ~-15K 32327(MDC1)(-)Loci: 3570 2136731-2141768 ~-5K 32330(TUBB2)(+)Loci: 3571 2300931-2316538 ~-16K 32336(DDR1)(+)Loci: 4848 2583391-2589717 ~-6K 32358(POU5F1)(-)Loci: 3572 2942907-2944177 ~-1K 32370(MCCD1)(+)Loci: 3573 2989472-2992233 ~-3K 32379(TNF)(+)Loci: 3574 3034720-3051660 ~-17K 32394(BAT2)(+)Loci: 4849 3100861-3117213 ~-16K 32408(BAT5)(-)Loci: 4850 3144482-3150469 ~-6K 32420(CLIC1)(-)Loci: 4851 3273206-3276937 ~-4K 32436(NEU1)(-)Loci: 4852 3366127-3373127 ~-7K 32450(RDBP)(-)Loci: 4853 3416089-3484322 ~-68K 32465(TNXB)(-)Loci: 4854 3490215-3503197 ~-13K 32467(CREBL1)(-)Loci: 4855 3569805-3599027 ~-29K 32497(NOTCH4)(-)Loci: 4845 1025321-1056177 ~-31K 32256(GABBR1)(-)Link out to UCSC  
Loci: 3576 882132-897414 ~-15K 32584(MOG)(+)Loci: 4860 1368158-1375605 ~-7K 32610(TRIM10)(-)Loci: 3577 1541880-1558353 ~-16K 32616(+)Loci: 4861 1914463-1929833 ~-15K 32644(MDC1)(-)Loci: 3578 1935034-1940072 ~-5K 32647(TUBB2)(+)Loci: 3579 2099260-2114867 ~-16K 32653(DDR1)(+)Loci: 4862 2381927-2388269 ~-6K 32673(POU5F1)(-)Loci: 3580 2744366-2745636 ~-1K 32685(MCCD1)(+)Loci: 3581 2790934-2793697 ~-3K 32694(TNF)(+)Loci: 3582 2836184-2853121 ~-17K 32708(BAT2)(+)Loci: 4863 2902325-2918686 ~-16K 32722(BAT5)(-)Loci: 4864 2945936-2951926 ~-6K 32734(CLIC1)(-)Loci: 4865 3074690-3078421 ~-4K 32743(NEU1)(-)Loci: 4866 3167604-3174600 ~-7K 32757(RDBP)(-)Loci: 4867 3377585-3406812 ~-29K 32798(NOTCH4)(-)Loci: 4859 827283-858139 ~-31K 32580(GABBR1)(-)Link out to UCSC  
Loci: 3523 29732787-29748126 ~-15K 30583(MOG)(+)Loci: 4776 29677984-29708839 ~-31K 30576(GABBR1)(-)Link out to UCSC