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0GA2L3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionGas2-like protein 3 (growth arrest-specific 2-like 3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The growth-arrest-specific protein 2 domain is found associated with the spectrin repeat.alponin homology domain and EF hand in many proteins.
  IPR003108:Growth-arrest-specific protein 2
The calponin homology domain (also known as CH-domain) is a superfamily of actin-binding domains found in both cytoskeletal proteins and signal transduction proteins . It comprises the following groups of actin-binding domains:Actinin-type (including spectrin.imbrin.BP-280) (see ).Calponin-type (see ).A comprehensive review of proteins containing this type of actin-binding domains is given in .The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity . Most proteins have two copies of the CH domain.owever some proteins such as calponin and the human vav proto-oncogene () have only a single copy. The structure of an example CH-domain has recently been solved .
  IPR001715:Calponin-like actin-binding
SequencesProtein: GA2L3_HUMAN (694 aa)
mRNA: NM_174942
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 26 residues, 99491619-99491694Exon2: 42 residues, 99509644-99509765Exon3: 18 residues, 99512783-99512831Exon4: 58 residues, 99518290-99518459Exon5: 40 residues, 99519546-99519662Exon6: 49 residues, 99529908-99530050Exon7: 23 residues, 99535652-99535716Exon8: 48 residues, 99536357-99536496Exon9: 38 residues, 99540183-99540291Exon10: 450 residues, 99541470-99542814Exon11: 2 residues, -Jump to GA2L3_HUMAN  
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Loci Cluster (Details)Loci: 2781 99275124-99339967 ~-65K 9512(+)Loci: 2782 99491619-99542814 ~-51K 9516(GAS2L3)(+)Loci: 4067 98987818-99060773 ~-73K 9498(-)Link out to UCSC