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0FZD8_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameFZD8
DescriptionFrizzled 8 precursor (frizzled-8) (fz-8) (hfz8).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (TAS)
0042813 Wnt receptor activity (TAS)
0007222 frizzled signaling pathway (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The frizzled (fz) locus of Drosophila coordinates the cytoskeletons of epidermal cells.roducing a parallel array of cuticular hairs and bristles . In fz mutants.he orientation of individual hairs with respect both to their neighbours and to the organism as a whole is altered. In the wild-type wing.ll hairs point towards the distal tip . In the developing wing.z has 2 functions: it is required for the proximal-distal transmission of an intracellular polarity signal; and it is required for cells to respond to the polarity signal. Fz produces an mRNA that encodes an integral membrane protein with 7 putative transmembrane (TM) domains. This protein should contain both extracellular and cytoplasmic domains.hich could function in the transmission and interpretation of polarity information . This signature is usually found downstream of the Fz domain ()
  IPR000539:Frizzled protein
The Frizzled CRD (cysteine rich domain) is conserved in diverse proteins including several receptor tyrosine kinases .In Drosophila melanogaster.embers of the Frizzled family of tissue-polarity genes encode proteins that appear to function as cell-surface receptors for Wnts. The Frizzled genes belong to the seven transmembrane class of receptors (7TMR) and have in their extracellular region a cysteine-rich domain that has been implicated as the Wnt binding domain. Sequence similarity between the cysteine-rich domain of Frizzled and several receptor tyrosine kinases.hich have roles in development include the muscle-specific receptor tyrosine kinase (MuSK).he neuronal specific kinase (NSK2).nd ROR1 and ROR2.The structure of this domain is known and is composed mainly of alpha helices.This domain contains ten conserved cysteines that form five disulphide bridges.These are shown in schematic form below
  IPR000024:Frizzled CRD region
IPR000539:Frizzled 
Evalue:-227.180450439453 
Location:267-623IPR000024:FRI 
Evalue:-72.0457574905607 
Location:34-153
SequencesProtein: FZD8_HUMAN (694 aa)
mRNA: NM_031866
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentK02534
  Level 3 annotation:
    frizzled 8
  Level 2 annotation:
    Wnt signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1063 residues, 35967182-35970368Exon2: 2 residues, -Jump to FZD8_HUMAN  
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Loci Cluster (Details)Loci: 2612 35934343-35937869 ~-4K 4733(+)Loci: 3887 35967182-35970368 ~-3K 4734(FZD8)(-)Loci: 2611 35455806-35541891 ~-86K 4712(+)Link out to UCSC