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0FUSIP_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameFUSIP1
DescriptionFus-interacting serine-arginine-rich protein 1 (tls-associated protein with ser-arg repeats) (tls-associated protein with sr repeats) (tasr) (tls-associated serine-arginine protein) (tls-associated sr protein) (40 kda sr-repressor protein) (srrp40) (splicing factor srp38).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (NAS)
0005654 nucleoplasm (IDA)
0031202 RNA splicing factor activity, transesterifi... (IDA)
0050733 RS domain binding (NAS)
0051082 unfolded protein binding (NAS)
0000244 assembly of spliceosomal tri-snRNP (NAS)
0016482 cytoplasmic transport (IDA)
0006376 mRNA splice site selection (IDA)
0006406 mRNA-nucleus export (NAS)
0048025 negative regulation of nuclear mRNA splicin... (IDA)
0000398 nuclear mRNA splicing, via spliceosome (IDA)
0045449 regulation of transcription (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Many eukaryotic proteins that are known or supposed to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids. This is known as the eukaryotic putative RNA-binding region RNP-1 signature or RNA recognition motif (RRM). RRMs are found in a variety of RNA binding proteins.ncluding heterogeneous nuclear ribonucleoproteins (hnRNPs).roteins implicated in regulation of alternative splicing.nd protein components of small nuclear ribonucleoproteins (snRNPs). The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialized features for protein recognition . The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich.ith a third helix present during RNA binding in some cases .
  IPR000504:RNA-binding region RNP-1 (RNA recognition motif)
This entry represents nucleotide-binding domains with an alpha-beta plait structure.hich consists of either a ferredoxin-like (beta-alpha-beta)2 fold.uch as that found in RNA-binding domains of various ribonucleoproteins or in viral DNA-binding domains . or a beta-(alpha)-beta-alpha-beta(2) fold.uch as that found in the ribosomal protein L23 .
  IPR012677:Nucleotide-binding, alpha-beta plait
IPR000504:RRM 
Evalue:-24.5528419686578 
Location:11-84
SequencesProtein: FUSIP_HUMAN (262 aa)
mRNA: AK001656 BC071575 NM_054016
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 786 residues, 24168159-24170516Exon2: 19 residues, 24170649-24170700Exon3: 56 residues, 24170926-24171089Exon4: 36 residues, 24174050-24174152Exon5: 37 residues, 24177787-24177894Exon6: 47 residues, 24179267-24179404Exon7: 2 residues, -Jump to FUSIP_HUMANExon1: 786 residues, 24168159-24170516Exon2: 20 residues, 24170649-24170703Exon3: 56 residues, 24170926-24171089Exon4: 36 residues, 24174050-24174152Exon5: 37 residues, 24177787-24177894Exon6: 49 residues, 24179267-24179408Exon7: 2 residues, -Jump to FUSIP_HUMANExon1: 354 residues, 24169457-24170516Exon2: 20 residues, 24170649-24170703Exon3: 56 residues, 24170926-24171089Exon4: 1102 residues, 24174050-24177350Exon5: 57 residues, 24177729-24177894Exon6: 47 residues, 24179267-24179404Exon7: 2 residues, -Jump to FUSIP_HUMANLoci index, Chromosomal location, Length, Possible relational loci clusterExon1: 788 residues, 1503240-1505601Exon2: 19 residues, 1505734-1505785Exon3: 56 residues, 1506011-1506174Exon4: 36 residues, 1509137-1509239Exon5: 37 residues, 1512873-1512980Exon6: 47 residues, 1514337-1514474Exon7: 2 residues, -Jump to FUSIP_HUMANExon1: 788 residues, 1503240-1505601Exon2: 20 residues, 1505734-1505788Exon3: 56 residues, 1506011-1506174Exon4: 36 residues, 1509137-1509239Exon5: 37 residues, 1512873-1512980Exon6: 49 residues, 1514337-1514478Exon7: 2 residues, -Jump to FUSIP_HUMANExon1: 354 residues, 1504542-1505601Exon2: 20 residues, 1505734-1505788Exon3: 56 residues, 1506011-1506174Exon4: 1101 residues, 1509137-1512436Exon5: 57 residues, 1512815-1512980Exon6: 47 residues, 1514337-1514474Exon7: 2 residues, -Jump to FUSIP_HUMAN  
Loci Cluster (Details)Loci: 3779 23390975-23393809 ~-3K 651(HTR1D)(-)Loci: 3780 23757042-23758872 ~-2K 667(ID3)(-)Loci: 3781 24000954-24024536 ~-24K 680(HMGCL)(-)Loci: 3782 24073047-24112404 ~-39K 686(CNR2)(-)Loci: 3783 24168159-24179408 ~-11K 691(FUSIP1)(-)Loci: 2490 23218532-23282771 ~-64K 646(AOF2)(+)Link out to UCSC