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0FTMT_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameFTMT
DescriptionFerritin, mitochondrial precursor (ec 1.16.3.1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Ferritin is one of the major non-haem iron storage proteins in animals.lants.nd microorganisms . It consists of a mineral core of hydrated ferric oxide.nd a multi-subunit protein shell that encloses the former and assures its solubility in an aqueous environment. In animals the protein is mainly cytoplasmic and there are generally two or more genes that encode closely related subunits - in mammals there are two subunits which are known as H(eavy) and L(ight). In plants ferritin is found in the chloroplast .This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.
  IPR008331:Ferritin and Dps
Ferritin is one of the major non-heme iron storage proteins in animals.lants.nd microorganisms . It consists of a mineral core of hydrated ferric oxide.nd a multi-subunit protein shell which encloses the former and assures its solubility in an aqueous environment. In animals the protein is mainly cytoplasmic and there are generally two or more genes that encode closely related subunits (in mammals there are two subunits which are known as H(eavy) and L(ight)). In plants ferritin is found in the chloroplast .
  IPR001519:Ferritin
Ferritin is one of the major non-haem iron storage proteins in animals.lants.nd microorganisms. Ferritin is a multisubunit protein with a hollow interior.hich contains a mineral core of hydrated ferric oxide.hereby ensuring its solubility in an aqueous environment . Each subunit consists of a closed.our-helical bundle with a left-handed twist and one crossover connection.This family contains ferritin and other ferritin-like proteins such as bacterioferritin (cytochrome b1) that binds haem between two subunits.on-haem ferritin.odecameric ferritin homologue (DPS) that binds to and protects DNA.nd the N-terminal domain of rubrerythrin that is found in many air-sensitive bacteria and archaea . In addition.ibonucleotide reductase-like proteins show a similar structure to the ferritin-like fold; these di-iron carboxylate proteins constitute a diverse class of non-haem iron enzymes performing a multitude of redox reactions . This family includes the alpha and beta subunits of methane monooxygenase hydrolase.elta 9-stearoyl-acyl carrier protein desaturase and manganese catalase (T-catalase).
  IPR009078:Ferritin/ribonucleotide reductase-like
This family represents ferritin and related proteins. Ferritin is a major non-haem iron storage protein in animal.lants and microorganisms . Iron is required by most organisms.ut is potentially toxic due to its reactivity.hich is counteracted by sequestering it into ferritin. Ferritin consists of a 4-helical bundle core.nd contains a bimetal-ion centre in the middle of the bundle. Other proteins with this structure include: haem-containing bacteriferritins; rubrerythrin.hich appears to have a role in anaerobic detoxification pathway for reactive oxygen species ; Dps (DNA-binding proteins from starved cells) used in bacteria for iron storage-detoxification; and CRD1 (AcsF).hich is required for the maintenance of photosystem I .
  IPR012347:Ferritin-related
IPR008331:Ferritin 
Evalue:-67.7447280883789 
Location:77-218IPR001519:FERRITIN_1 
Evalue:0 
Location:0-0
SequencesProtein: FTMT_HUMAN (242 aa)
mRNA: NM_177478
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00522
  Level 3 annotation:
    ferroxidase
  Level 2 annotation:
    Porphyrin and chlorophyll metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 291 residues, 121215548-121216420Exon2: 2 residues, -Jump to FTMT_HUMAN  
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