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0FPR1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameFPR1
Descriptionfmet-leu-phe receptor (fmlp receptor) (n-formyl peptide receptor) (fpr) (n-formylpeptide chemoattractant receptor).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005768 endosome (TAS)
0016021 integral to membrane (TAS)
0005886 plasma membrane (TAS)
0004982 N-formyl peptide receptor activity (TAS)
0004872 receptor activity (TAS)
0000187 activation of MAPK activity (TAS)
0006928 cell motility (TAS)
0006935 chemotaxis (TAS)
0007186 G-protein coupled receptor protein signalin... (TAS)
0007188 G-protein signaling, coupled to cAMP nucleo... (TAS)
0007263 nitric oxide mediated signal transduction (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Accumulation of phagocytic cells at sites of injury or infection isregulated by substances that stimulate chemotaxis.ranule secretion.uperoxide generation and up-regulation of cell surface adhesion moleculesin cells of the immune system. The chemoattractant substances includebacterial N-formyl-methionyl peptides (typified by fMet-Leu-Phe (fMLP)).any of which participate in pathophysiological conditions.uch asanaphylactic and septic shock. Three fMLP receptors have beenidentified: fMLP selectively activates the FPR1 receptor relative tothe FPR2 receptor; its action on FPR3 is unknown. The FPR1 receptor isfound in differentiated myeloid cells (i.e..eutrophils and monocytes).nd in related cell lines; the FPR2 receptor is found only in neutrophilsand monocytes (it binds fMLP at >1000 times higher concentrations thanat the FPR1 receptor.nd may bind other N-formyl-methionyl peptideswith higher affinity) .
  IPR000826:Formyl/methionyl peptide receptor
IPR000276:7tm_1 
Evalue:-53.6382713317871 
Location:43-301IPR000826:FMETLEUPHER 
Evalue:0 
Location:305-324
SequencesProtein: FPR1_HUMAN (350 aa)
mRNA: NM_002029
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
KO assignmentK04172
  Level 3 annotation:
    formyl peptide receptor 1
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 411 residues, 56940838-56942070Exon2: 30 residues, 56946878-56946962Exon3: 2 residues, -Jump to FPR1_HUMAN  
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Loci Cluster (Details)Loci: 4415 56940838-56946962 ~-6K 19471(FPR1)(-)Loci: 3134 57385045-57421482 ~-36K 19494(PPP2R1A)(+)Loci: 4414 56540220-56561484 ~-21K 19449(ETFB)(-)Link out to UCSC