SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0FMT_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMTFMT
DescriptionMethionyl-trna formyltransferase, mitochondrial precursor (ec 2.1.2.9) (mtfmt).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A number of formyl transferases belong to this group.Methionyl-tRNA formyltransferase transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl aminoacyl-tRNA. The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and by impairing its binding to EFTU-GTP.Formyltetrahydrofolate dehydrogenase produces formate from formyl- tetrahydrofolate. This is the N-terminal domain of these enzymes and is found upstream of the C-terminal domain ().The trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase catalyses the second.hird and fifth steps in de novo purine biosynthesis. The glycinamide ribonucleotide transformylase belongs to this group.
  IPR002376:Formyl transferase, N-terminal
Methionyl-tRNA formyltransferase () transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl aminoacyl-tRNA. The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and by impairing its binding to EFTU-GTP. The top-scoring characterized proteins other than methionyl-tRNA formyltransferase (fmt) itself are formyltetrahydrofolate dehydrogenases. The mitochondrial methionyl-tRNA formyltransferases are so divergent that.n a multiple alignment of bacterial fmt.itochondrial fmt.nd formyltetrahydrofolate dehydrogenases.he mitochondrial fmt appears the most different. However.ecause both bacterial and mitochondrial fmt are included in the seed alignment.ll credible fmt sequences score higher than any non-fmt sequence.
  IPR005794:Methionyl-tRNA formyltransferase
Methionyl-tRNA formyltransferase (FMT) () transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl aminoacyl-tRNA. The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and by impairing its binding to EFTU-GTP. This family also includes formyltetrahydrofolate dehydrogenases.hich produce formate from formyl-tetrahydrofolate. These enzymes contain an N-terminal domain in common with other formyl transferase enzymes (). The C-terminal domain has an open beta-barrel fold .The C-terminal domain of FMT structurally resembles methylpurine-DNA glycosylases (MPG). Human 3-methyladenine DNA glycosylase (AAG) catalyses the first step of base excision repair by cleaving damaged bases from DNA.xcising a chemically diverse selection of substrate bases damaged by alkylation or deamination .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011034:Formyl transferase, C-terminal-like
IPR002376:Formyl_trans_N 
Evalue:-22.0315170288086 
Location:48-220IPR011034:FMT_C_like 
Evalue:0 
Location:248-357
SequencesProtein: FMT_HUMAN (389 aa)
mRNA: BC033687
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00604
  Level 3 annotation:
    methionyl-tRNA formyltransferase
  Level 2 annotation:
    Methionine metabolism
    One carbon pool by folate
    Aminoacyl-tRNA biosynthesis
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 249 residues, 63081903-63082647Exon2: 29 residues, 63084244-63084327Exon3: 28 residues, 63085503-63085582Exon4: 32 residues, 63095826-63095918Exon5: 27 residues, 63099587-63099663Exon6: 36 residues, 63100904-63101007Exon7: 43 residues, 63103062-63103185Exon8: 72 residues, 63106221-63106431Exon9: 76 residues, 63108795-63109018Exon10: 2 residues, -Jump to FMT_HUMANExon1: 249 residues, 63081903-63082647Exon2: 29 residues, 63084244-63084327Exon3: 28 residues, 63085503-63085582Exon4: 32 residues, 63095826-63095918Exon5: 27 residues, 63099587-63099663Exon6: 36 residues, 63100904-63101007Exon7: 43 residues, 63103062-63103185Exon8: 72 residues, 63106221-63106431Exon9: 76 residues, 63108795-63109018Exon10: 2 residues, -Jump to FMT_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4176 63229837-63264616 ~-35K 12558(CLPX)(-)Loci: 4175 63081903-63109018 ~-27K 12552(MTFMT)(-)Link out to UCSC