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0FLT3L_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameFLT3LG
DescriptionSl cytokine precursor (fms-related tyrosine kinase 3 ligand) (flt3 ligand) (flt3l).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005625 soluble fraction (TAS)
0005102 receptor binding (TAS)
0008284 positive regulation of cell proliferation (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The flt3 (fms-related tyrosine kinase 3) ligand is a short chain cytokine with a 4 helical bundle fold. It is a type I membrane protein which stimulates the proliferation of of early hematopoeitic cells.nd synergises well with other colony stimulating factors and interleukins.
  IPR004213:Flt3 ligand
Members of this family display a core structure consisting of a closed bundle of four helices in a left-handed twist.ith two crossover connections. Family members include long-chain cytokines.uch as leukaemia inhibitory factor (LIF) .he growth hormone somatotropin .nterleukin-6 and leptin ; short-chain cytokines.uch as erythropoietin .tem cell factor (SCF) .acrophage colony-stimulating factor (M-CSF) and interleukin-2.3.4.5 and -13; and interferons/interleukin-10.Please be aware that some of the protein hits may be false positives.
  IPR009079:Four-helical cytokine
This entry represents a 4-helical bundle domain found predominantly in long- and short-chain cytokines.uch as interleukins.nterferons.rowth hormones.nd granulocyte colony stimulating factors. Cytokines play a crucial role in the development of an immune response by organising the recruitment and trafficking of immune cell populations throughout the body.sually through GPCR signalling . Most cytokines have a predominantly alpha helical structure.nd share a core domain consisting of a closed bundle of four helices in a left-handed twist.ith two crossover connections .
  IPR012351:Cytokine, four-helical bundle
IPR004213:Flt3_lig 
Evalue:-122.468521118164 
Location:27-159
SequencesProtein: FLT3L_HUMAN (235 aa)
mRNA: NM_001459
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentK05454
  Level 3 annotation:
    fms-related tyrosine kinase 3 ligand
  Level 2 annotation:
    Cytokines
    Cytokine-cytokine receptor interaction
    Hematopoietic cell lineage
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 18 residues, 54669297-54669350Exon2: 25 residues, 54669671-54669741Exon3: 39 residues, 54670759-54670870Exon4: 20 residues, 54671213-54671267Exon5: 50 residues, 54671491-54671635Exon6: 48 residues, 54673977-54674116Exon7: 61 residues, 54675366-54675545Exon8: 25 residues, 54675620-54675689Exon9: 74 residues, 54681083-54681299Exon10: 2 residues, -Jump to FLT3L_HUMAN  
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Loci Cluster (Details)Loci: 3124 53589943-53639205 ~-49K 19224(GRIN2D)(+)Loci: 3125 53656317-53661179 ~-5K 19226(KCNJ14)(+)Loci: 3126 53747240-53794495 ~-47K 19229(SULT2B1)(+)Loci: 4406 53833083-53841263 ~-8K 19240(CA11)(-)Loci: 4407 53990131-54006113 ~-16K 19255(BCAT2)(-)Loci: 4408 54262487-54268010 ~-6K 19284(-)Loci: 3127 54309429-54313528 ~-4K 19290(LIN7B)(+)Loci: 3128 54314474-54346090 ~-32K 19292(PPFIA3)(+)Loci: 4409 54484705-54520286 ~-36K 19297(SLC6A16)(-)Loci: 3129 54669297-54681299 ~-12K 19311(FLT3LG)(+)Loci: 4410 54854641-54860926 ~-6K 19323(IRF3)(-)Loci: 3130 54886218-54908800 ~-23K 19334(CPT1C)(+)Loci: 3131 54961991-55002179 ~-40K 19337(AP2A1)(+)Loci: 3132 55124271-55129003 ~-5K 19355(ATF5)(+)Loci: 4411 55510576-55524446 ~-14K 19365(KCNC3)(-)Loci: 4412 55817047-55833114 ~-16K 19382(SYT3)(-)Loci: 4413 55856895-55912007 ~-55K 19383(SHANK1)(-)Loci: 3123 53559468-53571439 ~-12K 19220(SYNGR4)(+)Link out to UCSC