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0FKB1B_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameFKBP1B
DescriptionFk506-binding protein 1b (ec 5.2.1.8) (peptidyl-prolyl cis-trans isomerase 1b) (ppiase 1b) (rotamase 1b) (12.6 kda fkbp) (fkbp-12.6) (immunophilin fkbp12.6) (h-fkbp-12).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (ISS)
0006936 muscle contraction (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Synonym(s): Peptidylprolyl cis-trans isomeraseFKBP-type peptidylprolyl isomerases () in vertebrates.re receptors for thetwo immunosuppressants.K506 and rapamycin. The drugs inhibit T cell proliferationby arresting two distinct cytoplasmic signal transmission pathways. Peptidylprolyl isomerases accelerate protein folding bycatalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.These proteins are found in a variety of organisms.
  IPR001179:Peptidylprolyl isomerase, FKBP-type
IPR001179:FKBP_C 
Evalue:-48.5850257873535 
Location:10-104
SequencesProtein: FKB1B_HUMAN (107 aa)
mRNA: BC002614 NM_004116
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 44 residues, 24126131-24126260Exon2: 18 residues, 24130275-24130323Exon3: 39 residues, 24137187-24137300Exon4: 222 residues, 24139392-24140052Exon5: 2 residues, -Jump to FKB1B_HUMANExon1: 44 residues, 24126131-24126260Exon2: 18 residues, 24130275-24130323Exon3: 39 residues, 24137187-24137300Exon4: 207 residues, 24139437-24140052Exon5: 2 residues, -Jump to FKB1B_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3148 24126131-24140052 ~-14K 20073(FKBP1B)(+)Loci: 4425 24279238-24436881 ~-158K 20080(ITSN2)(-)Loci: 4424 24105721-24123735 ~-18K 20071(-)Link out to UCSC