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0FIBA_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameFGA
DescriptionFibrinogen alpha chain precursor .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005576 extracellular region (NAS)
0005577 fibrinogen complex (TAS)
0005515 protein binding (IPI)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Fibrinogen plays key roles in both blood clotting and platelet aggregation. During blood clot formation.he conversion of soluble fibrinogen to insoluble fibrin is triggered by thrombin.esulting in the polymerisation of fibrin.hich forms a soft clot; this is then converted to a hard clot by factor XIIIA.hich further cross-links fibrin molecules. Platelet aggregation involves the binding of the platelet protein receptor integrin alpha(IIb)-beta(3) to the C-terminal domain of the fibrinogen gamma chain.ediating a range of adhesive reactions that include adhesion.latelet aggregation and fibrin clot retraction .Fibrinogen occurs as a dimer.here each monomer is composed of three non-identical chains.lpha.eta and gamma.inked together by several disulphide bonds . The N-terminals of all six chains come together to form the centre of the molecule.rom which the monomers extend in opposite directions as coiled coils.ollowed by C-terminal globular domains. The C-terminal globular domains are referred to as the D regions.hile the coiled-coil and N-terminal central region are referred to as the E region. During clot formation.he N-terminal alpha and beta chains are cleaved.nabling them to bind to the C-terminal gamma and beta chains.espectively.f adjacent molecules.ausing the proteins to polymerise .This entry represents the C-terminal globular domains (D region) of the alpha.eta and gamma chains. These domains are related to domains in other proteins: in the sea cucumber fibrogen-like FreP-A and FreP-B proteins; in the C-terminus of Drosophila scabrous protein that is involved in the regulation of neurogenesis.ossibly through the inhibition of R8 cell differentiation; and in ficolin proteins.hich display lectin activity towards N-acetylglucosamine through their fibrogen-like domains .
  IPR002181:Fibrinogen, alpha/beta/gamma chain, C-terminal globular
IPR002181:FBG 
Evalue:-129.187086643357 
Location:627-863
SequencesProtein: FIBA_HUMAN (866 aa)
mRNA: NM_000508
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK03903
  Level 3 annotation:
    fibrinogen, A alpha polypeptide
  Level 2 annotation:
    CAM ligands
    Complement and coagulation cascades
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 569 residues, 155723729-155725435Exon2: 462 residues, 155726139-155727520Exon3: 50 residues, 155728113-155728259Exon4: 63 residues, 155729394-155729578Exon5: 44 residues, 155730038-155730164Exon6: 39 residues, 155731235-155731347Exon7: 2 residues, -Jump to FIBA_HUMAN  
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