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0FHIT_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameFHIT
DescriptionBis(5'-adenosyl)-triphosphatase (ec 3.6.1.29) (diadenosine 5',5'''- p1,p3-triphosphate hydrolase) (dinucleosidetriphosphatase) (ap3a hydrolase) (ap3aase) (fragile histidine triad protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (IDA)
0047710 bis(5'-adenosyl)-triphosphatase activity (IDA)
0016787 hydrolase activity (IDA)
0009117 nucleotide metabolism (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The Histidine Triad (HIT) motif.is-phi-His-phi-His-phi-phi (phi.hydrophobic amino acid) was identified as being highly conserved in avariety of organisms . Crystal structure of rabbit Hint.urified as an adenosine and AMP-binding protein.howed that proteins in the HITsuperfamily are conserved as nucleotide-binding proteins and that Hinthomologs.hich are found in all forms of life.re structurally related toFhit homologs and GalT-related enzymes.hich have more restrictedphylogenetic profiles . Hint homologs including rabbit Hint and yeastHnt1 hydrolyze adenosine 5 monophosphoramide substrates such as AMP-NH2 andAMP-lysine to AMP plus the amine product and function as positive regulatorsof Cdk7/Kin28 in vivo . Fhit homologs are diadenosine polyphosphatehydrolases and function as tumor suppressors in human and mouse though the tumor suppressing function of Fhit does not depend on ApppAhydrolysis . The third branch of the HIT superfamily.hich includesGalT homologs.ontains a related His-X-His-X-Gln motif and transfersnucleoside monophosphate moeities to phosphorylated second substrates ratherthan hydrolyzing them .
  IPR001310:Histidine triad (HIT) protein
IPR001310:HIT 
Evalue:-36.9586067199707 
Location:9-104
SequencesProtein: FHIT_HUMAN (146 aa)
mRNA: NM_002012
Local Annotation
Synapse Ontology
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 90 residues, 59710077-59710345Exon2: 35 residues, 59712986-59713087Exon3: 25 residues, 59883111-59883180Exon4: 12 residues, 59972136-59972166Exon5: 50 residues, 59974772-59974918Exon6: 42 residues, 60497632-60497752Exon7: 33 residues, 60782652-60782745Exon8: 19 residues, 61002758-61002811Exon9: 18 residues, 61161330-61161379Exon10: 52 residues, 61212014-61212164Exon11: 2 residues, -Jump to FHIT_HUMAN