SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0FEZ2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameFEZ2
DescriptionFasciculation and elongation protein zeta 2 (zygin-2) (zygin ii).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (IPI)
0007411 axon guidance (TAS)
0007399 neurogenesis (TAS)
0007165 signal transduction (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/581274009.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This is a family of eukaryotic proteins thought to be involved in axonal outgrowth and fasciculation . The N-terminal regions of these sequences are less conserved than the C-terminal regions.nd are highly acidic . The Caenorhabditis elegans homolog.NC-76 ().ay play structural and signalling roles in the control of axonal extension and adhesion (particularly in the presence of adjacent neuronal cells ) and these roles have also been postulated for other FEZ family proteins . Certain homologs have been definitively found to interact with the N-terminal variable region (V1) of PKC-zeta.nd this interaction causes cytoplasmic translocation of the FEZ family protein in mammalian neuronal cells . The C-terminal region probably participates in the association with the regulatory domain of PKC-zeta . The members of this family are predicted to form coiled-coil structures which may interact with members of the RhoA family of signalling proteins .ut are not thought to contain other characteristic protein motifs . Certain members of this family are expressed almost exclusively in the brain.hereas others (such as FEZ2. are expressed in other tissues.nd are thought to perform similar but unknown functions in these tissues .
  IPR011680:FEZ-like
IPR011680:FEZ 
Evalue:-145.823913574219 
Location:46-289
SequencesProtein: FEZ2_HUMAN (353 aa)
mRNA: No corresponding mRNA found
Local Annotation
Synapse Ontology
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 306 residues, 36632909-36633826Exon2: 24 residues, 36636329-36636395Exon3: 27 residues, 36639084-36639160Exon4: 91 residues, 36659243-36659512Exon5: 49 residues, 36661936-36662078Exon6: 41 residues, 36663999-36664116Exon7: 38 residues, 36671549-36671658Exon8: 101 residues, 36678523-36678821Exon9: 2 residues, -Jump to FEZ2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4432 36632909-36678821 ~-46K 20263(FEZ2)(-)Loci: 3158 36436900-36631781 ~-195K 20259(CRIM1)(+)Link out to UCSC