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0FEZ1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameFEZ1
DescriptionFasciculation and elongation protein zeta 1 (zygin-1) (zygin i).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (IPI)
0007411 axon guidance (TAS)
0007155 cell adhesion (TAS)
0007399 neurogenesis (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This is a family of eukaryotic proteins thought to be involved in axonal outgrowth and fasciculation . The N-terminal regions of these sequences are less conserved than the C-terminal regions.nd are highly acidic . The Caenorhabditis elegans homolog.NC-76 ().ay play structural and signalling roles in the control of axonal extension and adhesion (particularly in the presence of adjacent neuronal cells ) and these roles have also been postulated for other FEZ family proteins . Certain homologs have been definitively found to interact with the N-terminal variable region (V1) of PKC-zeta.nd this interaction causes cytoplasmic translocation of the FEZ family protein in mammalian neuronal cells . The C-terminal region probably participates in the association with the regulatory domain of PKC-zeta . The members of this family are predicted to form coiled-coil structures which may interact with members of the RhoA family of signalling proteins .ut are not thought to contain other characteristic protein motifs . Certain members of this family are expressed almost exclusively in the brain.hereas others (such as FEZ2. are expressed in other tissues.nd are thought to perform similar but unknown functions in these tissues .
  IPR011680:FEZ-like
IPR011680:FEZ 
Evalue:-164.060485839844 
Location:58-300
SequencesProtein: FEZ1_HUMAN (392 aa)
mRNA: NM_005103
Local Annotation
Synapse Ontology
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 120 residues, 124820859-124821217Exon2: 24 residues, 124823607-124823673Exon3: 27 residues, 124827439-124827515Exon4: 29 residues, 124829235-124829316Exon5: 92 residues, 124830940-124831212Exon6: 58 residues, 124835603-124835772Exon7: 31 residues, 124838589-124838676Exon8: 35 residues, 124856639-124856739Exon9: 120 residues, 124864572-124864928Exon10: 37 residues, 124871226-124871333Exon11: 2 residues, -Jump to FEZ1_HUMAN  
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