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0FETUA_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameAHSG
DescriptionAlpha-2-hs-glycoprotein precursor (fetuin-a) (alpha-2-z-globulin) (ba- alpha-2-glycoprotein) .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005615 extracellular space (NAS)
0019210 kinase inhibitor activity (NAS)
0006953 acute-phase response (IDA)
0030502 negative regulation of bone mineralization (ISS)
0046627 negative regulation of insulin receptor sig... (NAS)
0006907 pinocytosis (NAS)
0050766 positive regulation of phagocytosis (IDA)
0050727 regulation of inflammatory response (IMP)
0001501 skeletal development (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Peptide proteinase inhibitors can be found as single domain proteins or as single or multiple domains within proteins; these are referred to as either simple or compound inhibitors.espectively. In many cases they are synthesised as part of a larger precursor protein.ither as a prepropeptide or as an N-terminal domain associated with an inactive peptidase or zymogen. Removal of the N-terminal inhibitor domain either by interaction with a second peptidase or by autocatalytic cleavage activates the zymogen. This family represent the cystatins.hich are cysteine proteinase inhibitors belonging to MEROPS inhibitor family I25.lan IH . They mainly inhibit peptidases belonging to peptidase families C1 (papain family) and C13 (legumain family). The cystatin family includes:The Type 1 cystatins.hich are intracellular cystatins that are present in the cytosol of many cell types.ut can also appear in body fluids at significant concentrations. They are single-chain polypeptides of about 100 residues.hich have neither disulphide bonds nor carbohydrate side chains. The Type 2 cystatins.hich are mainly extracellular secreted polypeptides synthesised with a 19-28 residue signal peptide. They are broadly distributed and found in most body fluids. The Type 3 cystatins.hich are multidomain proteins. The mammalian representatives of this group are the kininogens. There are three different kininogens in mammals: H- (high molecular mass. and L- (low molecular mass) kininogen which are found in a number of species.nd T-kininogen that is found only in rat. Unclassified cystatins. These are cystatin-like proteins found in a range of organisms: plant phytocystatins.etuin in mammals.nsect cystatins and a puff adder venom cystatin which inhibits metalloproteases of the MEROPS peptidase family M12 (astacin/adamalysin). Also a number of the cystatins-like proteins have been shown to be devoid of inhibitory activity.
  IPR000010:Proteinase inhibitor I25, cystatin
IPR000010:Cystatin 
Evalue:-22.4317989349365 
Location:150-239IPR000010:CY 
Evalue:-11.1549019599857 
Location:21-133
SequencesProtein: FETUA_HUMAN (367 aa)
mRNA: NM_001622
Local Annotation
Synapse Ontology
endocytosis may be initiated or blocked by all kinds of signal.
sdb:0257 regulation of endocytosis  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 86 residues, 187813580-187813837Exon2: 39 residues, 187816167-187816278Exon3: 30 residues, 187816925-187817010Exon4: 56 residues, 187817669-187817833Exon5: 36 residues, 187819018-187819120Exon6: 30 residues, 187820339-187820423Exon7: 245 residues, 187821068-187821799Exon8: 2 residues, -Jump to FETUA_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4653 187349939-187521190 ~-171K 26985(-)Loci: 3393 187813580-187821799 ~-8K 26990(AHSG)(+)Loci: 4652 187117235-187138450 ~-21K 26980(SFRS10)(-)Link out to UCSC