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0FBX39_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionF-box only protein 39.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The F-box domain was first described as a sequence motif found in cyclin-F that interacts with the protein SKP1 . This relatively conserved structural motif is present in numerous proteins and serves as a link between a target protein and a ubiquitin-conjugating enzyme. The SCF complex (e.g..kp1-Cullin-F-box) plays a similar role as an E3 ligase in the ubiquitin protein degradation pathway . DifferentF-box proteins as a part of SCF complex recruit particular substrates for ubiquitination through specific proteinprotein interaction domains. Many mammalian F-box domains contain leucine-rich or WD-40 repeats (). However.everal F-boxproteins either have other previously described domains such as Sec7 domain found in FBS protein or do not contain defined proteinproteininteraction domains or motifs.
  IPR001810:Cyclin-like F-box
Leucine-rich repeats (LRR) consist of 2-45 motifs of 20-30 amino acids in length that generally folds into an arc or horseshoe shape . LRRs occur in proteins ranging from viruses to eukaryotes.nd appear to provide a structural framework for the formation of protein-protein interactions . Proteins containing LRRs include tyrosine kinase receptors.ell-adhesion molecules.irulence factors.nd extracellular matrix-binding glycoproteins.nd are involved in a variety of biological processes.ncluding signal transduction.ell adhesion.NA repair.ecombination.ranscription.NA processing.isease resistance.poptosis.nd the immune response.Sequence analyses of LRR proteins suggested the existence of several different subfamilies of LRRs. The significance of this classification is that repeats from different subfamilies never occur simultaneously and have most probably evolved independently. It is.owever.ow clear that all major classes of LRR have curved horseshoe structures with a parallel beta sheet on the concave side and mostly helical elements on the convex side. At least six families of LRR proteins.haracterized by different lengths and consensus sequences of the repeats.ave been identified. Eleven-residue segments of the LRRs (LxxLxLxxN/CxL).orresponding to the ß-strand and adjacent loop conserved in LRR proteins.hereas the remaining parts of the repeats (herein termed variable) may be very different. Despite the differences.ach of the variable parts contains two half-turns at both ends and a "linear" segment (as the chain follows a linear path overall).sually formed by a helix.n the middle. The concave face and the adjacent loops are the most common protein interaction surfaces on LRR proteins. 3D structure of some LRR proteins-ligand complexes show that the concave surface of LRR domain is ideal for interaction with alpha-helix.hus supporting earlier conclusions that the elongated and curved LRR structure provides an outstanding framework for achieving diverse protein-protein interactions . Molecular modeling suggests that the conserved pattern LxxLxL.hich is shorter than the previously proposed LxxLxLxxN/CxL is sufficient to impart the characteristic horseshoe curvature to proteins with 20- to 30-residue repeats .
  IPR001611:Leucine-rich repeat
SequencesProtein: FBX39_HUMAN (442 aa)
mRNA: NM_153230
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 7 residues, 6620295-6620315Exon2: 369 residues, 6623831-6624934Exon3: 61 residues, 6630822-6630999Exon4: 117 residues, 6631342-6631688Exon5: 2 residues, -Jump to FBX39_HUMAN  
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Loci Cluster (Details)Loci: 4258 6644024-6675784 ~-32K 14997(TEKT1)(-)Loci: 4259 7033935-7063745 ~-30K 15014(DLG4)(-)Loci: 2974 7063876-7069308 ~-5K 15016(ACADVL)(+)Loci: 4260 7084462-7086477 ~-2K 15021(GABARAP)(-)Loci: 2975 7252225-7263903 ~-12K 15047(NLGN2)(+)Loci: 2976 7289129-7301655 ~-13K 15051(CHRNB1)(+)Loci: 2977 7427889-7432228 ~-4K 15066(MPDU1)(+)Loci: 2978 7474184-7477419 ~-3K 15071(SHBG)(+)Loci: 4261 7512446-7531642 ~-19K 15074(TP53)(-)Loci: 4262 7774391-7775983 ~-2K 15094(TRAPPC1)(-)Loci: 2979 7846716-7864382 ~-18K 15097(GUCY2D)(+)Loci: 4263 8004447-8006987 ~-3K 15108(VAMP2)(-)Loci: 2980 8093361-8114528 ~-21K 15119(PFAS)(+)Loci: 2981 8279988-8330396 ~-50K 15135(+)Loci: 2973 6620295-6631688 ~-11K 14996(FBXO39)(+)Link out to UCSC