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0FBW1B_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionF-box/wd-repeat protein 11 (f-box/wd-repeat protein 1b) (f-box and wd- repeats protein beta-trcp2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0000151 ubiquitin ligase complex (NAS)
0005515 protein binding (IPI)
0004842 ubiquitin-protein ligase activity (NAS)
0016567 protein ubiquitination (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The F-box domain was first described as a sequence motif found in cyclin-F that interacts with the protein SKP1 . This relatively conserved structural motif is present in numerous proteins and serves as a link between a target protein and a ubiquitin-conjugating enzyme. The SCF complex (e.g..kp1-Cullin-F-box) plays a similar role as an E3 ligase in the ubiquitin protein degradation pathway . DifferentF-box proteins as a part of SCF complex recruit particular substrates for ubiquitination through specific proteinprotein interaction domains. Many mammalian F-box domains contain leucine-rich or WD-40 repeats (). However.everal F-boxproteins either have other previously described domains such as Sec7 domain found in FBS protein or do not contain defined proteinproteininteraction domains or motifs.
  IPR001810:Cyclin-like F-box
WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs.ften terminating in a Trp-Asp (W-D) dipeptide. WD-containing proteins have 4 to 16 repeating units.ll of which are thought to form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. The underlying common function of all WD-repeat proteins is coordinating multi-protein complex the repeating units serve as a rigid scaffold for protein interactions. The specificity of the proteins is determined by the sequences outside the repeats themselves. Examples of such complexes are G proteins (beta subunit is a beta-propeller).AFII transcription factor.nd E3 ubiquitin ligase .
  IPR001680:WD-40 repeat
The WD40 motif is found in a multitude of eukaryotic proteins involved in a variety of cellular processes . Repeated WD40 motifs act as a site for protein-protein interaction.nd proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. In Arabidopsis sp..everal WD40-containig proteins act as key regulators of plant-specific developmental events. WD40 repeats usually assume a 7-8 bladed beta-propeller fold.ut proteins have been found with 4 to 16 repeated units.The structures of several WD40 repeat-containing proteins have been determined.ncluding the beta-1 subunit of the signal-transducing G protein heterotrimer.he C-terminal domain of yeast Tup1.he C-terminal domain of Groucho/tle1.he Cdc4 propeller domain.he bovine Arp2/3 complex 41 kDa subunit ARPC1.nd actin interacting protein 1. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
SequencesProtein: FBW1B_HUMAN (542 aa)
mRNA: NM_012300
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK03362
  Level 3 annotation:
    SCF complex F-box protein MET30
  Level 2 annotation:
    Ubiquitin mediated proteolysis
    Wnt signaling pathway
    Hedgehog signaling pathway
    Cell cycle
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 851 residues, 171221160-171223710Exon2: 64 residues, 171228218-171228405Exon3: 28 residues, 171229337-171229416Exon4: 39 residues, 171230356-171230467Exon5: 41 residues, 171232480-171232599Exon6: 85 residues, 171235893-171236143Exon7: 41 residues, 171237619-171237738Exon8: 48 residues, 171251075-171251213Exon9: 32 residues, 171258612-171258703Exon10: 64 residues, 171259522-171259709Exon11: 77 residues, 171270180-171270406Exon12: 36 residues, 171317205-171317307Exon13: 140 residues, 171366066-171366482Exon14: 2 residues, -Jump to FBW1B_HUMAN  
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