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0FBLI1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameFBLIM1
DescriptionFilamin-binding lim protein 1 (filamin-binding lim protein 1) (fblp-1) (mitogen-inducible 2 interacting protein) (mig2-interacting protein) (migfilin).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Recently . number of proteins have been found to contain a conserved cysteine-rich domain of about 60 amino-acid residues. These proteins are:Caenorhabditis elegans mec-3; a protein required for the differentiation of the set of six touch receptor neurons in this nematode.C. elegans. lin-11; a protein required for the asymmetric division of vulval blast cells.Vertebrate insulin gene enhancer binding protein isl-1. Isl-1 binds to one of the two cis-acting protein-binding domains of the insulin gene.Vertebrate homeobox proteins lim-1.im-2 (lim-5) and lim3.Vertebrate lmx-1.hich acts as a transcriptional activator by binding to the FLAT element; a beta-cell-specific transcriptional enhancer found in the insulin gene.Mammalian LH-2. transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types.Drosophila melanogaster protein apterous.equired for the normal development of the wing and halter imaginal discs.Vertebrate protein kinases LIMK-1 and LIMK-2.Mammalian rhombotins. Rhombotin 1 (RBTN1 or TTG-1) and rhombotin-2 (RBTN2 or TTG-2) are proteins of about 160 amino acids whose genes are disrupted by chromosomal translocations in T-cell leukemia.Mammalian and avian cysteine-rich protein (CRP). 192 amino-acid protein of unknown function. Seems to interact with zyxin.Mammalian cysteine-rich intestinal protein (CRIP). small protein which seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.Vertebrate paxillin. cytoskeletal focal adhesion protein.Mouse testin which should not be confused with rat testin which is a thiol protease homolog (see ).Sunflower pollen specific protein SF3.Chicken zyxin. Zyxin is a low-abundance adhesion plaque protein which has been shown to interact with CRP.Yeast protein LRG1 which is involved in sporulation .Yeast rho-type GTPase activating protein RGA1/DBM1.C. elegans homeobox protein ceh-14.C. elegans homeobox protein unc-97.Yeast hypothetical protein YKR090w.C. elegans hypothetical proteins C28H8.6.These proteins generally have two tandem copies of a domain.alled LIM (for Lin-11 Isl-1 Mec-3) in their N-terminal section. Zyxin and paxillin are exceptions in that they contains respectively three and four LIM domains at their C-terminal extremity. In apterous.sl-1.H-2.in-11.im-1 to lim-3.mx-1 and ceh-14 and mec-3 there is a homeobox domain some 50 to 95 amino acids after the LIM domains.In the LIM domain.here are seven conserved cysteine residues and a histidine. The arrangement followed by these conserved residues is C-x(2)-C-x(16.3)-H-x(2)-[CH]-x(2)-C-x(2)-C-x(16.1)-C-x(2.)-[CHD]. The LIM domain binds two zinc ions . LIM does not bind DNA.ather it seems to act as an interface for protein-protein interaction.
  IPR001781:LIM, zinc-binding
IPR001781:LIM 
Evalue:-16.7958793640137 
Location:183-241IPR001781:LIM 
Evalue:-12.1426675035687 
Location:242-294IPR001781:LIM 
Evalue:-10.4202164033832 
Location:302-363
SequencesProtein: FBLI1_HUMAN (373 aa)
mRNA: NM_017556
Local Annotation
Synapse Ontology
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
sdb:0033 regulation of synapse structure  (Evidence:keywords)
the specialized cytoskeletal scaffold that is anchored to the presynaptic membrane, and it varies in morphology.
sdb:0103 specialized cytoskeletal scaffold  (Evidence:keywords)
cytoskeleton filaments is one kind of structural components to maintain synapse morphology and bear the related function which is connected with the synaptic morphology.
sdb:0280 cytoskeletal filaments  (Evidence:keywords)
actin exists in two states within the cell: as polymerized two-stranded helical filaments (F-actin) or as monomers (Gactin), which provide the building blocks for filament assembly.
sdb:0283 G-actin  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 30 residues, 15957841-15957930Exon2: 65 residues, 15963577-15963767Exon3: 92 residues, 15964045-15964315Exon4: 64 residues, 15966457-15966645Exon5: 36 residues, 15967609-15967712Exon6: 58 residues, 15969490-15969660Exon7: 61 residues, 15973699-15973878Exon8: 41 residues, 15976251-15976369Exon9: 683 residues, 15983629-15985673Exon10: 2 residues, -Jump to FBLI1_HUMAN  
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Loci Cluster (Details)Loci: 2483 15935395-15940471 ~-5K 460(+)Loci: 2484 15957841-15985673 ~-28K 462(FBLIM1)(+)Loci: 3772 15771738-15784192 ~-12K 455(AGMAT)(-)Link out to UCSC