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0F264_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePFKFB4
Description6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (6pf-2-k/fru- 2,6-p2ase testis-type isozyme) .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003873 6-phosphofructo-2-kinase activity (NAS)
0006003 fructose 2,6-bisphosphate metabolism (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
6-Phosphofructo-2-kinase (. is a bifunctional enzyme that catalyses both the synthesis and the degradation of fructose-2.-bisphosphate. The fructose-2.-bisphosphatase reaction involves a phosphohistidine intermediate. The catalytic pathway is:ATP + D-fructose 6-phosphate = ADP + D-fructose 2.-bisphosphateD-fructose 2.-bisphosphate + H2O = 6-fructose 6-phosphate + PiThe enzyme is important in the regulation of hepatic carbohydrate metabolism and is found in greatest quantities in the liver.idney and heart. In mammals.everal genes often encode different isoforms.ach of which differs in its tissue distribution and enzymatic activity . The family described here bears a resemblance to the ATP-driven phospho-fructokinases.owever.hey share little sequence similarity.lthough a few residues seem key to their interaction with fructose 6-phosphate .This domain forms the N-terminal region of this enzyme.hile forms the C-terminal domain.
  IPR013079:6-phosphofructo-2-kinase
Phosphoglycerate mutase () (PGAM) and bisphosphoglycerate mutase () (BPGM) are structurally related enzymes that catalyse reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate . Both enzymes can catalyse three different reactions with different specificities.he isomerization of 2-phosphoglycerate (2-PGA) to 3-phosphoglycerate (3-PGA) with 2.-diphosphoglycerate (2.-DPG) as the primer of the reaction.he synthesis of 2.-DPG from 1.-DPG with 3-PGA as a primer and the degradation of 2.-DPG to 3-PGA (phosphatase activity).In mammals.GAM is a dimeric protein with two isoforms.he M (muscle) and B (brain) forms. In yeast.GAM is a tetrameric protein. BPGM is a dimeric protein and is found mainly in erythrocytes where it plays a major role in regulating haemoglobin oxygen affinity as a consequence of controlling 2.-DPG concentration. The catalytic mechanism of both PGAM and BPGM involves the formation of a phosphohistidine intermediate . A number of other proteins including.he bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2.-bisphosphatase that catalyses both the synthesis and the degradation of fructose-2.-bisphosphate and bacterial alpha-ribazole-5-phosphate phosphatase.hich is involved in cobalamin biosynthesis.ontain this domain .
  IPR013078:Phosphoglycerate mutase
6-Phosphofructo-2-kinase (. is a bifunctional enzyme that catalyses both the synthesis and the degradation of fructose-2.-bisphosphate. The fructose-2.-bisphosphatase reaction involves a phosphohistidine intermediate. The catalytic pathway is:ATP + D-fructose 6-phosphate = ADP + D-fructose 2.-bisphosphateD-fructose 2.-bisphosphate + H2O = 6-fructose 6-phosphate + PiThe enzyme is important in the regulation of hepatic carbohydrate metabolism and is found in greatest quantities in the liver.idney and heart. In mammals.everal genes often encode different isoforms.ach of which differs in its tissue distribution and enzymatic activity . The family described here bears a resemblance to the ATP-driven phospho-fructokinases.owever.hey share little sequence similarity.lthough a few residues seem key to their interaction with fructose 6-phosphate .
  IPR003094:Fructose-2,6-bisphosphatase
IPR013079:6PF2K 
Evalue:-152.161148071289 
Location:29-248IPR013078:PGAM 
Evalue:-45.0087738037109 
Location:250-397
SequencesProtein: F264_HUMAN (468 aa)
mRNA: NM_004567
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK00900
  Level 3 annotation:
    6-phosphofructo-2-kinase
  Level 2 annotation:
    Fructose and mannose metabolism
K01103
  Level 3 annotation:
    fructose-2,6-bisphosphatase
  Level 2 annotation:
    Fructose and mannose metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 706 residues, 48530128-48532243Exon2: 23 residues, 48534422-48534487Exon3: 23 residues, 48535973-48536036Exon4: 45 residues, 48536137-48536267Exon5: 37 residues, 48538001-48538106Exon6: 51 residues, 48547948-48548095Exon7: 71 residues, 48548692-48548900Exon8: 42 residues, 48550934-48551056Exon9: 21 residues, 48551690-48551747Exon10: 27 residues, 48552133-48552208Exon11: 24 residues, 48556016-48556083Exon12: 34 residues, 48562300-48562397Exon13: 41 residues, 48562554-48562671Exon14: 40 residues, 48569117-48569231Exon15: 2 residues, -Jump to F264_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4601 48530128-48569231 ~-39K 25651(PFKFB4)(-)Loci: 4602 48611435-48622102 ~-11K 25656(UQCRC1)(-)Loci: 4603 48637834-48684985 ~-47K 25658(CELSR3)(-)Loci: 4604 48686283-48698338 ~-12K 25669(NCKIPSD)(-)Loci: 4605 48762098-48860265 ~-98K 25672(-)Loci: 4606 49133551-49145603 ~-12K 25699(LAMB2)(-)Loci: 4607 49429215-49435016 ~-6K 25713(AMT)(-)Loci: 3354 49566925-49683976 ~-117K 25718(BSN)(+)Loci: 4608 49921309-49942261 ~-21K 25739(-)Loci: 4609 50330243-50333903 ~-4K 25774(HYAL2)(-)Loci: 4600 48420266-48441746 ~-21K 25634(PLXNB1)(-)Link out to UCSC